Administration of anti-glial cell line-derived neurotrophic factor (anti-GDNF) antibodies reduces liver fibrosis development in mice. Administration of.

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FK506 Controls CD40L-Induced Systemic Autoimmunity in Mice

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Administration of anti-glial cell line-derived neurotrophic factor (anti-GDNF) antibodies reduces liver fibrosis development in mice. Administration of anti-glial cell line-derived neurotrophic factor (anti-GDNF) antibodies reduces liver fibrosis development in mice. (A) Anti-GDNF-blocking antibodies blunted carbon tetrachloride (CCl4)-induced liver injury (intraperitoneal injections; Ab1: 400 ng/g BW; Ab2: 400 ng/g BW administered for 3 weeks (once a week), starting from the second week after CCl4 treatment); controls were treated with IgG (400 ng/g BW). (B, C) Sirius red and α-SMA staining (original magnification, ×100). The positive stained area was calculated as a percentage. Col1α1 and α-Sma mRNA expression levels are shown as the fold downregulation in comparison to untreated animals. Bars indicate the mean±SD of three independent experiments; n=6 per group; one-way analysis of variance with the non-parametric Kruskal-Wallis test was used in parts A–C. Le Tao et al. Gut doi:10.1136/gutjnl-2018-317872 Copyright © BMJ Publishing Group Ltd & British Society of Gastroenterology. All rights reserved.