Ann-Marie M. Schoos, MD, PhD, Bo L

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Presentation transcript:

Sensitization trajectories in childhood revealed by using a cluster analysis Ann-Marie M. Schoos, MD, PhD, Bo L. Chawes, MD, PhD, DMSc, Erik Melén, MD, PhD, Anna Bergström, PhD, Inger Kull, PhD, Magnus Wickman, MD, PhD, Klaus Bønnelykke, MD, PhD, Hans Bisgaard, MD, DMSc, Morten A. Rasmussen, PhD Journal of Allergy and Clinical Immunology Volume 140, Issue 6, Pages 1693-1699 (December 2017) DOI: 10.1016/j.jaci.2017.01.041 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Positive registrations in relative frequency of the 13 allergens at the 4 age points. Journal of Allergy and Clinical Immunology 2017 140, 1693-1699DOI: (10.1016/j.jaci.2017.01.041) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Pairwise comparison of latent patterns between the COPSAC2000 (gray) and BAMSE (black) data, showing groups of specific allergen patterns that follow a similar profile in both time and participants. A, Unit normal sensitization pattern loadings. The x-axis describes loading magnitude. B, Time-development pattern loadings. The y-axis describes loading magnitude. Journal of Allergy and Clinical Immunology 2017 140, 1693-1699DOI: (10.1016/j.jaci.2017.01.041) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Association between sensitization patterns and clinical outcomes for COPSAC2000 data (n = 398, black) and for children of asthmatic mothers for BAMSE data (n = 282) at 4 years (light gray) and 8 years (dark gray) of age. For asthma and rhinitis, the comparison is done with logistic regression, and for eczema in COPSAC2000, the comparison is done with Cox regression and in BAMSE with logistic regression. Journal of Allergy and Clinical Immunology 2017 140, 1693-1699DOI: (10.1016/j.jaci.2017.01.041) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Age-dependent associations between patterns and clinical outcomes shown as OR/hazard ratio (HR; black line) with 95% CIs (dotted line) in COPSAC2000. Some estimates for patterns 1 to 5 at the ages of ½ and 1½ years are omitted because of numbers of positive sensitization registrations were too low for the particular pattern. Included are association results based on clustering from all time points (black star with error bars). Journal of Allergy and Clinical Immunology 2017 140, 1693-1699DOI: (10.1016/j.jaci.2017.01.041) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions