The benefits: exercise and cardiometabolic disease

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Presentation transcript:

The benefits: exercise and cardiometabolic disease Dominique Hansen, PhD, FESC

Faculty Disclosure The presenter has advised that the following presentation will NOT include discussion on any commercial products or service and that there are NO financial interests or relationships with any of the Commercial Supporters of this years ASM.

Exercise in cardiovascular disease: guidelines Piepoli MF, et al. Eur J Prev Cardiol 2016;23:NP1-96

But do we follow and implement these guidelines?

Do we adhere to the guidelines?

Do we adhere to the guidelines?

Do we adhere to the guidelines?

Physical activity in healthy people: why?

Physical activity in healthy people: why?

Physical activity in healthy people: why? 149,077 participants over an 8.9-year (median) follow-up

Seven days of bed rest in healthy individuals leads to: 1.4 kg muscle mass loss 7% reduction in muscle strength 8% reduction in skeletal muscle oxidative capacity 6% reduction in VO2peak 29% reduction in insulin sensitivity Dirks M, et al. Diabetes. 2016; 65: 2862-75

Physical activity in people with cardiometabolic disease: why?

Importance of CVD risk factor management

Role of exercise in hypertension

Role of exercise in hypertension

Role of exercise in dyslipidaemia

But patient phenotype matters…

And statin intake matters…

Role of exercise in obesity

What is then the role of exercise in obesity? Ross R, et al J Appl Physiol 1996; 81: 2445-55 20

What is then the role of exercise in obesity? Duration of endurance exercise Mittendorfer B, et al. Am J Physiol 2004; 286: E354 21

What is then the role of exercise in obesity?

What is then the role of exercise in obesity? Larson-Meyer DE, et al. Med Sci Sports Exerc 2010; 42: 152 23

What is then the role of exercise in obesity? Ross R, et al J Appl Physiol 1996; 81: 2445-55

What is then the role of exercise in obesity?

What is then the role of exercise in obesity? fatness vs fitness

Role of exercise in type 2 diabetes

Role of exercise in type 2 diabetes Umpierre D, et al. JAMA 2011; 305: 1790-99

Role of exercise in type 1 diabetes

Imp act on glycaemic variability?

Imp act on glycaemic variability?

Role of exercise in deconditioning

Role of exercise in deconditioning Dependency

Role of exercise in deconditioning

Economic impact of exercise

Role of exercise in coronary artery disease

Role of exercise in coronary artery disease

Role of exercise in coronary artery disease

Role of exercise in coronary artery disease

Role of exercise in heart failure

Role of exercise in heart failure

Role of exercise in heart failure

Role of exercise in heart failure

Role of exercise in heart failure

Role of exercise in heart failure

Conclusions Exercise intervention is potent to improve CVD risk, and lead to better treatment of cardiometabolic disease However, current gaps in knowledge should be addressed and clinicians must be aware of what exercise is not capable of doing (yet)

https://twitter.com/hansen_phd Contact: Dominique.hansen@uhasselt.be https://twitter.com/hansen_phd https://www.researchgate.net/profile/Dominique_Hansen2