Phenotypic diversity of less predominant B-lineage clones. Phenotypic diversity of less predominant B-lineage clones. Immune phenotypes of cells of less predominant clones (in black) were visualized. The areas presumably representing physiologic and/or malignant plasma cell phenotypes are circled in blue. While cells of the second predominant clone of multiple myeloma 2 (A) colocalize with normal-phenotype B lymphocytes, cells of the second and third predominant clones in multiple myeloma 3 (B) map to areas that have been shown to be occupied with multiple myeloma cells in Fig. 3. See Supplementary Fig. S6 for detailed immune phenotypes. Leo Hansmann et al. Cancer Immunol Res 2017;5:744-754 ©2017 by American Association for Cancer Research