CD36 expression is coordinately regulated in multiple cellular compartments. CD36 expression is coordinately regulated in multiple cellular compartments.

Slides:

Advertisements

Similar presentations

Tumor CompartmentStromal Compartment mask C D EF A B Supplemental Fig 1. Epithelial and stromal PD-L1 expression. AQUA scores for PD-L1 in the epithelium.

Advertisements

Glioma-derived soluble factor(s) enhance IL-10 signaling.

Figure 1. Cellular distribution of a disintegrin and metalloproteinases (ADAM)-9 expression in hepatocellular carcinoma (HCC) and non-tumorous liver tissues.

CD25 expression is associated with unfavorable clinical outcome.

PD-1 and LAG-3 expression in MSI and MSS colorectal cancer specimens.

Geographic distribution in situ of MSI and MSS colorectal cancer–infiltrating lymphocytes. Geographic distribution in situ of MSI and MSS colorectal cancer–infiltrating.

IHC staining of FFPE esophageal tissues in tissue microarrays (×20).

High-throughput analysis of informative CpG sites for the four studied tumor suppressor genes (A-D). High-throughput analysis of informative CpG sites.

Tumor intrinsic subtype is reflected in cancer-adjacent tissue.

Effects of SC144 on in vivo ovarian tumor.

The STM1787 promoter in Salmonella is rapidly activated in vivo by the tumor microenvironment. The STM1787 promoter in Salmonella is rapidly activated.

Representative multiplex immunofluorescence image of synovial sarcoma with increased PD-L1/PD-1/CD8 cell densities at the tumor-invasive margin demonstrating.

Macrophage-specific ablation of Vegfa in PyMT implant tumors blocks blood vessel permeability and tumor cell intravasation at the TMEM. A and C, immunofluorescence.

Tregs and APC subsets in TDLNs of patients with cervical cancer.

IHC staining of various cystic structures

Phosphorylation of TRIO Y2681 in human colorectal cancer (CRC) is correlated with poorer prognosis. Phosphorylation of TRIO Y2681 in human colorectal cancer.

Effect of antiangiogenic TKIs and rMVA–CEA–TRICOM vaccine on tumor compactness, tight junctions, and intratumoral pressure in the MC38-CEA model. Effect.

B cells infiltrate mouse and human pancreatic neoplasia and promote growth of KrasG12D-PDEC in vivo. B cells infiltrate mouse and human pancreatic neoplasia.

NICD1 immunohistochemical staining in normal and tumor tissue.

ILK knockdown decreases mTOR signaling in PKD kidneys.

A, DEAR1 and SMAD3 immunohistochemical staining in human breast cancer tissues. A, DEAR1 and SMAD3 immunohistochemical staining in human breast cancer.

SIRT1 is downregulated in human gastric cancer (GC).

Metformin and rapamycin decreased tumor weights in obese prediabetic mice. Metformin and rapamycin decreased tumor weights in obese prediabetic mice. A:

TFAP2A is highly expressed in nasopharyngeal carcinoma cells and tumor tissues. TFAP2A is highly expressed in nasopharyngeal carcinoma cells and tumor.

Interacting MDSCs and mast cells (MC) in human colon carcinoma and in the colon of AOM/DSS-induced tumor-bearing mice. Interacting MDSCs and mast cells.

Immunohistochemical analyses of SHH expression levels in nonmalignant prostate and adenocarcinoma tissues. Immunohistochemical analyses of SHH expression.

Correlation of RSPO expression to LGR5 expansion in gastric cancer.

Geographic colocalization of PD-L1+ tumor cells with infiltrating immune cells in MCC. The predominant pattern of tumor cell PD-L1 expression is at the.

FAK overexpression in invasive human breast cancer and DCIS

FAK overexpression in invasive human colon cancer and colon dysplasia.

AXL is not expressed in human prostate tumors.

Antitumor activity of MLN8237 against TNBC patient-derived tumor xenografts (PDTX) in vivo. Antitumor activity of MLN8237 against TNBC patient-derived.

A, TSG-6 staining in TRAMP tissue and TRAMP cell lines.

Transplantable HMLEHRASV12 xenografts show multilocular lipid droplets and express beige/brown adipocyte–specific proteins. Transplantable HMLEHRASV12.

Cisplatin plus PTUPB decreases proliferation and angiogenesis but increases apoptosis as determined by immunohistochemical (IHC) analysis. Cisplatin plus.

IL-13Rα2 expression is associated to human colon cancer progression and poor survival of patients with colorectal cancer. IL-13Rα2 expression is associated.

Endothelial cells/microvasucles are increased in prostate cancer versus normal tissues. Endothelial cells/microvasucles are increased in prostate cancer.

CD4+ and CD8+ TILs express surface CD137.

Immunohistochemical analysis of dUTPase in human breast adenocarcinoma

MET amplification is selected in KRAS wild-type colorectal cancer samples from patients who developed resistance to anti-EGFR treatment. MET amplification.

Ki-67 expression in M31- and H3-treated tumors (A) and respective Ki-67 labeling indices in the two groups of tumors (B). Ki-67 expression in M31- and.

CA-MSCs differentially secrete GM-CSF.

Tumor cell clusters with increased tumorigenesis, metastasis, and CD44 expression. Tumor cell clusters with increased tumorigenesis, metastasis, and CD44.

Reduced klotho expression in pancreatic cancer.

In vivo demonstration of EMT in GFP-tagged tumors.

HMQ1611 inhibited breast tumor growth in mice.

Met is expressed in Her2-overexpressing cell lines and Her2 (+) breast tumors. Met is expressed in Her2-overexpressing cell lines and Her2 (+) breast tumors.

MYC–HOXB7–HER2 predicts clinical outcome in breast cancer patients treated with tamoxifen. MYC–HOXB7–HER2 predicts clinical outcome in breast cancer patients.

Enrichment and detection of CTCs from orthotopic xenograft models of GBM. A, immunohistologic analysis of coronal sections showing mCherry expressing GBM8.

Activation status of CD8+ T cells.

Progastrin staining in colon adenomas and adenocarcinomas.

Histology (H&E; original magnification, ×100 for B-2P/C-12P/C-64P and ×40 for C-10P; top) of small-sized lung adenocarcinomas and immunohistochemical staining.

In situ hybridization of Calu-6 tumors using PDGFRα and PDGFRβ probes.

Reduced expression of the tumor suppressor PTEN occurs in tumors with both squamous cell and adenocarcinoma histology. Reduced expression of the tumor.

Establishment and characterization of primary CAFs from patients with colorectal cancer. Establishment and characterization of primary CAFs from patients.

In situ expression of signature genes in the Th1, Th2, Th17, and Treg pathways. In situ expression of signature genes in the Th1, Th2, Th17, and Treg pathways.

Mutational load and mutations in the interferon signaling pathway among patients with advanced melanoma with or without response to anti–PD-1 blockade.

Detection of microcalcifications in 4T1 mammary tumors and human breast tumor tissue. Detection of microcalcifications in 4T1 mammary tumors and human.

CD36 expression in tissue adjacent and distal to the tumor.

BIM expression predicts the response of patients with EGFR-mutant lung cancers. BIM expression predicts the response of patients with EGFR-mutant lung.

HER2 amplification in EGFRT790M–negative tumors with acquired resistance. HER2 amplification in EGFRT790M–negative tumors with acquired resistance. A,HER2.

Expression of the angiogenic phenotype in the 4-NQO mouse model of HNSCC. A, tissue sections containing areas of normal, hyperkeratosis, dysplasia, and.

PEGPH20 depletes HA and decompresses intratumoral vessels.

Determination of Per2 (left), MTNR1A (middle), and ERβ (right) protein expression levels in mammary tissues of rats sacrificed at ZT12. Determination of.

Epithelial and stromal percentage clusterin staining in normal nonadjacent colonic tissue and matched tumor tissue in 202 patients with stage II colorectal.

Coincidence and prognostic significance of PD-1+ and CD103+ cells in HGSC. Serial sections from the 490-case TMA were stained with antibodies to CD103.

IHC staining of FFPE esophageal tissues in tissue microarrays (×20).

Intratumoral spatial distribution of granulocytes and T cells.

(A–E) demonstrate a kidney biopsy from a patient with lupus nephritis (LN) class V. Representative micrographs: (A), an inflammatory infiltrate with T.

GSN and DNMT1 expression are inversely correlated in a pattern associated with patient survival. GSN and DNMT1 expression are inversely correlated in a.

Presentation transcript:

CD36 expression is coordinately regulated in multiple cellular compartments. CD36 expression is coordinately regulated in multiple cellular compartments. A, left: representative bright field images (original magnification ×20) of paraffin sections from 13 low mammographic density and 14 high mammographic density tissues stained for CD36. Right: average and SEM of CD36 signal per cell. B, representative bright field images (original magnification ×5) of paraffin sections with tumor and normal adjacent tissue from 8 ER-positive tumors, 6 HER2-positive tumors, and 6 triple negative tumors stained for CD36. C, average and SEM of CD36 signal per cell for each tumor subtype. D, left: representative bright field images (original magnification ×20) of paraffin sections from 21 low mammographic density and 14 high mammographic density ER-positive IDC patients stained for CD36. Right: average and SEM of CD36 signal per cell. CA, tumor; HD, high mammographic density; LD, low mammographic density; NA, normal adjacent, TN, triple negative. Rosa Anna DeFilippis et al. Cancer Discovery 2012;2:826-839 ©2012 by American Association for Cancer Research