Effect of sacubitril/valsartan on the rate of primary end point and component and all-cause mortality in patients randomised in the PARADIGM-HF trial according.

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Eric J Robinson, M.D. Cardiologist April 25, 2015

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From: Cost-Effectiveness of Sacubitril-Valsartan Combination Therapy Compared With Enalapril for the Treatment of Heart Failure With Reduced Ejection Fraction.

Journal of Cardiac Failure

Site Selection and Performance in Clinical Trials

CLINICAL DILEMMAS IN HEART FAILURE:

Echocardiographic images of aortic sclerosis showing (A) a normal valve in the parasternal short axis and (B) a zoom view in the parasternal long axis,

PARADIGM-HF Trial design: Participants with NYHA class II-IV and LVEF ≤40% were randomized to LCZ mg twice daily (n = 4,187) vs. enalapril 10 mg.

Challenging the Myths in Heart Failure With Reduced Ejection Fraction

The results of systematic literature search of published studies investigating the potential uses of WhatsApp within healthcare. The results of systematic.

Stepwise treatment of patients with symptomatic (NYHA II–IV) heart failure with reduced ejection fraction. Stepwise treatment of patients with symptomatic.

Hazard ratios for the composite primary end-point from sub-group analyses of patents presenting with and without an acute coronary syndrome. Hazard ratios.

12 lead ECG from a patient with reverse typical atrial flutter confirmed at electrophysiological study. 12 lead ECG from a patient with reverse typical.

Chart 3: Working example of oxygen section for hospital prescription charts (two panels are required on the prescription chart because oxygen may change.

A, B, C, D show outcome results for individual symptoms using GSRS-IBS scoring system and mean symptom severity scores before and after IBS dietetic management.

Masashi Maeda et al. Heart Asia 2013;5:7-14

The Arclight illumination uses a light emitting diode placed directly below the viewing hole, facing the patient, creating a near-axial light source unlike.

Global differences in national policy emphasis on children’s mental health compared with that nation’s minimum age of criminal responsibility (MACR). Global.

A, B, C, D show outcome results for individual symptoms using GSRS-IBS scoring system and mean symptom severity scores before and after IBS dietetic management.

Time course of changes in left ventricular ejection fraction (LVEF) and left ventricular diastolic dimension (LVDd) in 13 patients with the development.

Relationship between the change in left ventricular ejection fraction (ΔLVEF) and change in left ventricular diastolic dimension (ΔLVDd) at 4 years at.

Algorithm for the investigation of patients with elevated cardiac troponin concentrations in the context of an alternative acute illness. Algorithm for.

Predicted mortality for intra-admission change in albumin for four different admission values of albumin, calculated for a 74-year-old man with Charlson.

Mean change from baseline in 6MWD in (A) Chinese patients with PAH in PATENT-1 and (B) Chinese patients with CTEPH in CHEST-1. Mean change from baseline.

Jordan B. King et al. JCHF 2016;4:

ASCOT: randomised trial showing a decrease in cardiovascular mortality in patients treated with amlodipine/perindopril compared with atenolol/thiazide.

Deaths by cause and sex, UK

Difference in the risk of MACEs in patients treated with anti–IL17 agents compared with the placebo in RCTs. IL,interleukin; MACEs, major adverse cardiovascular.

The first Bedside Assessment, Stabilisation and Initial Cardiorespiratory Support (BASICS) prototype (by PW in April 2011, reprinted with his permission).

Difference in the risk of MACEs in patients treated with anti-IL23 agents compared with the placebo in RCTs. IL, interleukin; MACEs, major adverse cardiovascular.

Predicted mortality for intra-admission change in alanine aminotransferase (ALT), calculated for a 74-year-old man with Charlson Index of 1, no heart failure,

Results of comparisons of treatments in the network.

(A) The ECG of a middle aged woman who was otherwise healthy but suffered a ventricular fibrillation cardiac arrest while receiving 20 mg daily of thioridazine.

Angiogram of total cavopulmonary connection.

Effect of sacubitril/valsartan on the rate of heart failure (HF) hospitalisations as a time to first event analysis and as a recurrent event analysis of.

Difference in the risk of MACEs in patients treated with anti-TNF agents compared with the placebo in RCTs. MACEs, major adverse cardiovascular events;

Number of patients needed to detect effect sizes in comparative outcome studies, and actual mean number and range of patients included in comparative trials.

Percentage of individuals aged 16 and over taking cardiovascular-related prescriptions, by sex, England 2012–2013. Percentage of individuals aged 16 and.

Use of evidence-based cardiac medications before, during and after hospitalisation for the index event in (A) overall ACS population and (B) patients with.

Countries and areas of the Western Pacific region included within the scope of this study. Taiwan does not have WHO Member State status but is within this.

Two types of VT (panel A and B) in the same patient (panel C during sinus rhythm). Two types of VT (panel A and B) in the same patient (panel C during.

One to one ventriculo-atrial conduction during VT

Kaplan-Meier survival curves by frequency of exacerbations in patients with COPD: group A, patients with no acute exacerbations of COPD; group B, patients.

Left atrial appendage flow during atrial fibrillation, as determined by pulsed Doppler during transoesophageal echocardiography. Left atrial appendage.

Correlation between age-standardised colorectal cancer incidence (left panel) and mortality rates (right panel) and human development index (HDI) in both.

The QT interval responses to different pacing rates in a patient in group I. The pacing rate was decreased from 110 to 50 beats/min and the QT interval.

Hazard ratios for the composite primary end-point from sub-group analyses of patents presenting with and without an acute coronary syndrome. Hazard ratios.

Stepwise treatment of patients with symptomatic (NYHA II–IV) heart failure with reduced ejection fraction. Stepwise treatment of patients with symptomatic.

Kaplan-Meier plot for the prespecified primary endpoint (CARE-HF (A) and the secondary composite endpoint (all-cause mortality and new onset heart failure.

Apical four chamber view in a patient with a bioprosthetic mitral valve and spontaneous echo contrast seen in the left ventricle. Apical four chamber view.

Performance of the Manchester Acute Coronary Syndromes decision rule with high-sensitivity cardiac troponin T (hs-cTnT) as the reference standard for the.

Temporal trends of AF hospitalisation per 100 patients with AF according to main hospitalisation causes between 2006 and *P value for increase trends

Standardised right ventricular perfusion images used for segmental analysis in patients with congenitally corrected TGA. (A) Transaxial (cross sectional)

Forest plot of major bleeding: the measure of the effect of morphine versus nonmorphine on major bleeding in each study was plotted using OR and 95% CI.

Performance of the Manchester Acute Coronary Syndromes decision rule in the validation study. Performance of the Manchester Acute Coronary Syndromes decision.

This section, cut in the frontal plane, in a human embryo at Carnegie stage 16, shows the entry of the pulmonary vein to the inferior aspect of the left.

Venn diagrams comparing numbers of CHA2DS2-VASc risk factors captured in primary care (blue), secondary care (green) and in both sources linked (combined).

Coloured dotplot of mortality rate per population in Scotland by age for those aged 30 to 89 years, from 1974 to 2015, stratified by sex for IHD.

Odds ratio (95% confidence intervals) of reporting respiratory symptoms in patients with treated hypothyroidism or inflammatory bowel disease (IBD) compared.

The primary mechanism of action of colchicine is tubulin disruption and thus the inhibition of microtubule polymerisation, an essential component of cellular.

Determinants of moderate Cardiovascular Health Index Score (achieving three or more risk factor targets), stratified by region conventions as in figure.

Predicted mortality for intra-admission change in albumin, calculated for a 74-year-old man with Charlson Index of 1, no heart failure, admission albumin.

Proportions of the social isolation—AMI and stroke excess risk mediated by biological, behavioural, socioeconomic and health-related factors. Proportions.

(A) Trends in colorectal cancer incidence and mortality in males (M) and females (F) by country (group 1: increasing or stable incidence and mortality).

Comparison of heart failure admissions rates per annum (recorded hospital admissions/ population at risk) in western developed countries 1978 to.

Change of LV filling pattern with exercise.

Plasma concentration of BNP according to age (A) in newborn infants from the first to the 14th day of life, and (B) in infants older than two weeks, children,

Relationship between 6-month all-cause mortality and the three types of heart failure adjusted for age ≥75 years, peripheral edema at admission, systolic.

The cumulative incidence curve demonstrated that patients with a sub-optimal LDL-C response to statin therapy were associated with a higher risk of CVD.

Survival free of atrial fibrillation after implantation of an implantable cardioverter defibrillator in our series (151 patients): overall population (solid.

Presentation transcript:

Effect of sacubitril/valsartan on the rate of primary end point and component and all-cause mortality in patients randomised in the PARADIGM-HF trial according to age group.27 p for interaction for cardiovascular (CV) death or heart failure (HF) hospitalisation=0.94, for CV death p for interaction=0.92, for HF hospitalisation p for interaction=0.81 and all-cause death p for interaction=0.99. Effect of sacubitril/valsartan on the rate of primary end point and component and all-cause mortality in patients randomised in the PARADIGM-HF trial according to age group.27 p for interaction for cardiovascular (CV) death or heart failure (HF) hospitalisation=0.94, for CV death p for interaction=0.92, for HF hospitalisation p for interaction=0.81 and all-cause death p for interaction=0.99. PARADIGM-HF, Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure. Pardeep S Jhund, and John J V McMurray Heart 2016;102:1342-1347 Copyright © BMJ Publishing Group Ltd & British Cardiovascular Society. All rights reserved.