Understanding the Basics of Dementia-Related Psychosis

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Presentation transcript:

Understanding the Basics of Dementia-Related Psychosis

Dementia

Etiological Subtype of Major and Mild NCDs

Dementia-Related Psychosis

Prevalence of Dementia and DRP in the USA

Diagnosis of DRP

Excluding Non-Dementia-Related Causes for Psychotic Symptoms

Measuring the Type, Frequency, Severity, Pattern, and Timing of Psychosis Symptoms in Clinical Practice

Neurobiology of NPS in Patients With Dementia

Neurobiology of NPS in Patients With Dementia (cont)

Potential Role of Genetics in DRP

Burden of DRP on Caregiver

AA Recommendations for the Nonpharmacologic Approach to BPSD

Rationale for Antipsychotic Therapy

Mechanism of Action of Atypical Antipsychotics

Efficacy of Antipsychotics in Patients With DRP

Safety of Antipsychotics in Patients With DRP

Rationale for SSRI Therapy in DRP

Efficacy and Safety of SSRIs

Rationale for Combining Acetylcholinesterase Inhibitors and Memantine in Treating DRP

Efficacy of AChEI + Memantine on DRP Posthoc Analysis of Pooled Data From 3 RCTs

Efficacy of AChEI + Memantine on DRP Posthoc Analysis of Pooled Data From 3 RCTs

Rational for the Use of Pimavanserin to Treat DRP

Phase 2 RDBPC Trial of the Efficacy and Safety of Pimavanserin in Patients With AD and Psychosis

Phase 2 RDBPC Trial of the Efficacy and Safety of Pimavanserin in Patients With AD Prespecified Subgroup Analysis in Patients With Severe Psychosis

Ongoing Clinical Studies for Psychosis in DPR

Conclusions

Abbreviations

Abbreviations (cont)

Abbreviations (cont)