Gabor-domain optical coherence tomography to aid in Mohs resection of basal cell carcinoma Patrice Tankam, PhD, Jonathan Soh, MD, Cristina Canavesi,

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Presentation transcript:

Gabor-domain optical coherence tomography to aid in Mohs resection of basal cell carcinoma Patrice Tankam, PhD, Jonathan Soh, MD, Cristina Canavesi, PhD, MBA, Mara Lanis, BS, Adam Hayes, PhD, Andrea Cogliati, PhD, Jannick P. Rolland, PhD, Sherrif F. Ibrahim, MD, PhD Journal of the American Academy of Dermatology Volume 80, Issue 6, Pages 1766-1769 (June 2019) DOI: 10.1016/j.jaad.2018.09.029 Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 A, Biopsy-proven basal cell carcinoma (BCC) outlined during Mohs procedure. The inked margin surrounding the tumor represents the marked and drawn margin by the surgeon. Margins I-IV are defined at 3, 12, 9, and 6 o'clock, respectively. A ruler straddling the drawn margin provides reference for Gabor-domain optical coherence microscopy (GD-OCM) images. A steri-strip is positioned 27 mm from the ink on margin I to serve as a reference mark for GD-OCM image analysis after the Mohs procedure. 3D images with a field of view of 1 mm2 were captured every millimeter for 6 mm, starting from 1 mm inside the drawn margin up to 4 mm outside. B and C, GD-OCM en-face images of 2 biopsy-proven BCCs. B1-B6 and C1-C6, Six different locations collected along 1 margin. The slices represent the cut through the anterior dermis. White and black arrows represent tumors and hair follicles, respectively. The first case (B) is a nodular BCC in which the real tumor margin was identified 1-2 mm from the drawn margin (B3 and B4). The second case (C) is a superficial BCC in which the tumor extended beyond 4 mm from the drawn margin. Bar represents 100 μm. Journal of the American Academy of Dermatology 2019 80, 1766-1769DOI: (10.1016/j.jaad.2018.09.029) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Gabor-domain optical coherence microscopy (GD-OCM) cross-section (parallel to optical axis) and en-face image (perpendicular to optical axis) comparison of healthy skin (A), nodular basal cell carcinoma (BCC) (B), and superficial BCC (C). The superficial BCC case was reported as not specified on the original biopsy (Table I).1 White and black arrows represent tumors and hair follicles, respectively. Green dashed lines on the cross-section images (A1, B1, and C1) represent the cut-through locations of the en-face images (A2, B2, and C2, respectively). Orange dashed lines on the en-face images (A2, B2, and C2) represent the cut-through locations of the cross-section images (A1, B1, and C1, respectively). Unlike the nodular BCC, where the cross-section image clearly shows a nodule of tumor (B1), tumor can be barely identified in the cross-section image of the superficial BCC (C1). In this case, viewing the en-face image was critical to confirming the presence of tumor (C2). B3 and C3, Histologic staining of slices from the corresponding patients. Video-nodular-BCC and Video-superficial-BCC show the 3D images of cases B and C. Bar represents 100 μm. Journal of the American Academy of Dermatology 2019 80, 1766-1769DOI: (10.1016/j.jaad.2018.09.029) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions