Driver pathways and key genes in OSCC

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Driver pathways and key genes in OSCC Driver pathways and key genes in OSCC. A, pathway alteration in each sample is indicated by a black box. Driver pathways and key genes in OSCC. A, pathway alteration in each sample is indicated by a black box. Sample identifier sequences are shown at the top and pathway names at the left. Selected clinical variables and clusters from Fig. 3 are indicated with colored boxes. B, Notch pathway. C, mitogenic signaling pathway. D, cell-cycle pathway. E, TP53 pathway. Pathway diagrams indicate the genes included in each pathway. Copy gains are indicated with red, copy losses with blue, mutations with black, and methylation with purple. Percentages shown indicate the frequency of that event. Curtis R. Pickering et al. Cancer Discovery 2013;3:770-781 ©2013 by American Association for Cancer Research