Cell junctions and CELL INCLUSIONS

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Presentation transcript:

Cell junctions and CELL INCLUSIONS

Three types of cell junctions: 1. Occluding junctions: seal cells together into sheets (forming an impermeable barrier) 2. Anchoring junctions: attach cells (and their cytoskeleton) to other cells or extracellular matrix (providing mechanical support) 3. Communicating junctions: allow exchange of chemical/electrical information between

Tight junction Each cell possesses integral membrane proteins that bind to similar proteins in the adjacent, forming a continuous “weld”

Anchoring junctions Integral membrane proteins connect a cell’s cytoskeleton to another cell or extracellular matrix

Desmosomes Cadherins attach to intermediate filaments via anchoring proteins: a desmosome

Gap junctions Gap junctions allow cells to exchange electrical and/or chemical signals Composed of proteins that form channels that allow small molecules to pass. Subunits of these channels are connexins that are assembled together to make connexons. The connexons from 2 cells join together to make a gap junction.

Gap junctions

CELL INCLUSIONS

Glycogen

Lipds

Hemoglobin

Zymogen

CRYSTALLINE INCLUSIONS

Lipofuscin Lipofuscin

Melanin

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