Obesity Genes—It's All About the Parents! Sadaf Farooqi  Cell Metabolism  Volume 9, Issue 6, Pages 487-488 (June 2009) DOI: 10.1016/j.cmet.2009.05.008 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Parent of Origin Effects for GNAS1 Mutations The paternal allele of GNAS1 is imprinted (poorly expressed—shown as a red cross) in a target tissue (such as the PVN in the brain), so maternal transmission (pink panel) of a null mutation (arrow) in AHO patients or mBrGsKO mice would result in little or no Gsα expression and, therefore, would be associated with obesity. In contrast, paternal transmission (blue panel) of a null mutation in pBrGsKO mice should result in a similar level of Gsα expression to that found in controls (because the mutation is on the imprinted allele) and should not be associated with obesity. Cell Metabolism 2009 9, 487-488DOI: (10.1016/j.cmet.2009.05.008) Copyright © 2009 Elsevier Inc. Terms and Conditions