Fig. 1. APP/PS1;C3 KO mice show improved cognitive flexibility (reversal) compared to APP/PS1 mice at 16 months of age. APP/PS1;C3 KO mice show improved.

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From: Propofol Limits Microglial Activation after Experimental Brain Trauma through Inhibition of Nicotinamide Adenine Dinucleotide Phosphate Oxidase Anesthes.

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Supplementary Figure 1. Deficits in cognitive function persist up to 11 wks post-injury in moderate-level CCI TBI mice. Sham-injured and CCI TBI mice.

Fig. 2. Increased Aβ plaque load in 16-month-old APP/PS1;C3 KO mice.

Cognitive deficits in APPPS1‐21 mice.

Fig. 5. Circulating PPi concentration does not correlate with severity of calcification phenotype in mice. Circulating PPi concentration does not correlate.

Fig. 6. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. C3 deficiency resulted in partial sparing.

Fig. 1. APP/PS1;C3 KO mice show improved cognitive flexibility (reversal) compared to APP/PS1 mice at 16 months of age. APP/PS1;C3 KO mice show improved.

Fig. 1 SDPS induces deficits in rat spatial memory that are reversed by imipramine. SDPS induces deficits in rat spatial memory that are reversed by imipramine.

MRSA virulence proteins cause LMC death and diminished CLV function

Fig. 4 Infection-induced CLV dysfunction is associated with decreased LMC coverage. Infection-induced CLV dysfunction is associated with decreased LMC.

Fig. 7 Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors. Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors.

Fig. 4. Perampanel ameliorates behavioral deficits in mice expressing the Thorase variants. Perampanel ameliorates behavioral deficits in mice expressing.

Fig. 4. Plaque-associated microglia and astrocytes and brain cytokines were altered in APP/PS1;C3 KO mice compared to APP/PS1 mice. Plaque-associated microglia.

Fig. 5 Local gel scaffold for T cell memory response.

Fig. 3. Morphological changes associated with glial activation were reduced in 16-month-old APP/PS1;C3 KO mice. Morphological changes associated with glial.

Deficiency in myeloid-resident NRP1 affects systemic metabolism.

Fig. 6 Transmissibility of adiposity from humanized mice to germ-free recipients. Transmissibility of adiposity from humanized mice to germ-free recipients.

Fig. 6 In utero injection of inflammatory cytokines or adoptive transfer of activated T cells leads to pregnancy loss. In utero injection of inflammatory.

Fig. 4 The extracellular domain of sortilin is sufficient for BDNF/TrkB signaling. The extracellular domain of sortilin is sufficient for BDNF/TrkB signaling.

Fig. 3 Sortilin deletion unmasks NTSR2 signaling.

Fig. 4 Whisker deprivation–induced remapping is stable beyond the deprivation period. Whisker deprivation–induced remapping is stable beyond the deprivation.

Fig. 1 KCC2 down-regulation is prevented in sortilin-deficient mice.

Fig. 1. Loss of circadian rhythms in iKO mice.

Fig. 4 Labeling of Msmeg with DMN-Tre is fast and specific and depends on Ag85A function. Labeling of Msmeg with DMN-Tre is fast and specific and depends.

Fig. 5. Microarray analysis of tumors treated by dabrafenib, trametinib, or the combination of dabrafenib and trametinib with pmel-1 ACT or mock ACT. Microarray.

Fig. 1. MSCs undergo in vivo apoptosis after infusion without affecting immunosuppression. MSCs undergo in vivo apoptosis after infusion without affecting.

Fig. 6. TIV-09, but not MIV-09, induces an IFN signature in the blood of vaccinated individuals at day 1. TIV-09, but not MIV-09, induces an IFN signature.

Glucose tolerance in WT and TRPM2-KO mice.

Fig. 2. Deficiency of neuronal HS leads to reduced neuroinflammation.

Fig. 4 Deletion of hepatocyte HIF-2α does not affect obesity-induced glucose, glucagon, and insulin intolerance. Deletion of hepatocyte HIF-2α does not.

Slc7a5 deficiency stimulates osteoclastogenesis in vitro.

Hepatic fuel metabolism in male 5αR1-KO and WT mice

Fig. 3 Biological function of TG2 and the interaction with MT-2.

Fig. 5. Vitamin B12 supplementation in the host altered the transcriptome of P. acnes in the skin microbiota. Vitamin B12 supplementation in the host altered.

Nuclear accumulation of NFATc1 increases in Slc7a5-deficient osteoclasts. Nuclear accumulation of NFATc1 increases in Slc7a5-deficient osteoclasts. BMMs.

Fig. 3. Increased expression of exhaustion markers and apoptosis markers on CAR8 cells in the presence of TCR antigen. Increased expression of exhaustion.

Fig. 1. CAR4 and CAR8 cells demonstrate in vitro and in vivo antileukemic efficacy. CAR4 and CAR8 cells demonstrate in vitro and in vivo antileukemic efficacy.

Fig. 5 Treatment with BMS (PO BID) protects from wasting and colitis in two SCID mouse models. Treatment with BMS (PO BID) protects from.

Fig. 4 Reconstitution of MCs in KitW-sh/W-sh mice increases IL-10+ Breg cells and suppresses the CHS response. Reconstitution of MCs in KitW-sh/W-sh mice.

The microchip-based drug delivery device and overview of study design

Fig. 3. Morphological changes associated with glial activation were reduced in 16-month-old APP/PS1;C3 KO mice. Morphological changes associated with glial.

Fig. 6. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. C3 deficiency resulted in partial sparing.

NicA2-J1 prevents nicotine addiction–like behavior during withdrawal

Cytokine expression in the ileum and colon.

Fig. 3 Local Maraba treatment of TNBC tumors provides long-term systemic protection. Local Maraba treatment of TNBC tumors provides long-term systemic.

Fig. 1. The HCN channel blocker ivabradine (IVA) is analgesic in a mouse model of type 1 diabetes. The HCN channel blocker ivabradine (IVA) is analgesic.

Fig. 2 Effect of CSF sTREM2– and CSF sTREM2–to–p-tau181 ratio on changes in cognition. Effect of CSF sTREM2– and CSF sTREM2–to–p-tau181 ratio on changes.

Fig. 8. Purkinje cell quantification and hearing threshold in NPC cats administered IC HPβCD. Purkinje cell quantification and hearing threshold in NPC.

Targeting p53-dependent stem cell loss for intestinal chemoprotection

Fig. 4. Plaque-associated microglia and astrocytes and brain cytokines were altered in APP/PS1;C3 KO mice compared to APP/PS1 mice. Plaque-associated microglia.

Fig. 6. Confocal image series at 10-μm intervals through the full retinal thickness at P48 in WT and vldlr-null mice. Confocal image series at 10-μm intervals.

Fig. 7 FAE-20 increases hippocampal excitability and leads to more stable contextual fear memory in mice. FAE-20 increases hippocampal excitability and.

Fig. 5 Increased myometrial cell contractility in response to fetal T cells from preterm infants. Increased myometrial cell contractility in response to.

In vivo prophylactic and therapeutic efficacy of C12G6 in mice

Fig. 1. GDF15 is up-regulated with obesity, and AAV-GDF15 improves metabolic parameters in DIO mice. GDF15 is up-regulated with obesity, and AAV-GDF15.

Fig. 7 Heart-specific OMA1 down-regulation protects from hypertrophy induced by TAC. Heart-specific OMA1 down-regulation protects from hypertrophy induced.

Fig. 2 BX795 is nontoxic to HCE cells at therapeutic concentration.

Fig. 2. Mechanism of PD-L1 down-regulation in NOD HSPCs.

Fig. 2. Col IV–Ac2-26 NPs increase subendothelial collagen in Ldlr−/− mice with established atherosclerosis. Col IV–Ac2-26 NPs increase subendothelial.

ATP analogs have little effect on the conformation of the 2CARD domain

Fig. 3. Association between peak CTL019 expansion and response.

Fig. 3. Col IV–Ac2-26 NPs suppress lesional superoxide and increase lesional Il10 mRNA in Ldlr−/− mice with established atherosclerosis. Col IV–Ac2-26.

Fig. 1 Differentiation of human peripheral blood monocytes into MDMi cells induces a microglial gene expression and functional phenotype. Differentiation.

Fig. 2 NGS bisulfite sequencing assay of DNA methylation in esophageal biopsies. NGS bisulfite sequencing assay of DNA methylation in esophageal biopsies.

γδ T cells producing IL-17 are required for short-term memory.

Fig. 4 Systemic AAV9 delivery of gene editing components to ΔEx44 mice rescues dystrophin expression. Systemic AAV9 delivery of gene editing components.

Fig. 3 Ect2 gene inactivation lowers cardiomyocyte endowment and is lethal in mice. Ect2 gene inactivation lowers cardiomyocyte endowment and is lethal.

Fig. 2. Cellular response to FolamiRs in vitro.

Fig. 2. In vivo local CD25-targeted NIR-PIT induces regression of treated LL/2-luc tumors. In vivo local CD25-targeted NIR-PIT induces regression of treated.

Fig. 6. Connectivity and mobility maps for Lesotho.

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Fig. 1. APP/PS1;C3 KO mice show improved cognitive flexibility (reversal) compared to APP/PS1 mice at 16 months of age. APP/PS1;C3 KO mice show improved cognitive flexibility (reversal) compared to APP/PS1 mice at 16 months of age. (A) Percent of mice that reached criterion (≥80% correct choices on each individual day) in the water T-maze test. Compared to WT mice, APP/PS1 mice were impaired in acquisition (day 2) and reversal learning and memory (days 4 and 5) (*P < 0.05, **P < 0.01). APP/PS1;C3 KO mice performed significantly better than did APP/PS1 mice (##P < 0.01), but similar to WT and C3 KO mice, in the reversal test on days 4 and 5, suggesting better cognitive flexibility in APP/PS1;C3 KO mice compared to APP/PS1 mice. (B) In total, fewer APP/PS1 mice reached the reversal criterion (≥80% correct choices over two consecutive days) (*P < 0.05), whereas the percent of WT, C3 KO, and APP/PS1;C3 KO mice that reached criterion in the reversal test was higher compared to APP/PS1 mice (***P < 0.001), indicating that C3 deficiency in APP/PS1 mice had both age-dependent and AD-related effects (WT, n = 13; APP/PS1, n = 11; APP/PS1;C3 KO, n = 10; C3 KO, n = 11). Tests were assessed using one-way analysis of variance (ANOVA) followed by Fisher’s protected least significant difference post hoc test. Qiaoqiao Shi et al., Sci Transl Med 2017;9:eaaf6295 Copyright © 2017, American Association for the Advancement of Science