Cytotoxic T Lymphocyte Antigen-4 Down-Regulates T Helper 1 Cells by Increasing Expression of Signal Transducer and Activator of Transcription 3 in Acute.

Slides:



Advertisements
Similar presentations
Interferon-α: A Potentially Effective Treatment for Minimal Residual Disease in Acute Leukemia/Myelodysplastic Syndrome after Allogeneic Hematopoietic.
Advertisements

Epstein-Barr Virus–Related Post-Transplantation Lymphoproliferative Disorder after Unmanipulated Human Leukocyte Antigen Haploidentical Hematopoietic.
Extramedullary Relapse of Acute Leukemia after Haploidentical Hematopoietic Stem Cell Transplantation: Incidence, Risk Factors, Treatment, and Clinical.
Increased Plasma Indoleamine 2,3-Dioxygenase Activity and Interferon-γ Levels Correlate with the Severity of Acute Graft-versus-Host Disease after Allogeneic.
Tumor Necrosis Factor-α Gene Polymorphisms Are Associated with Severity of Acute Graft-Versus-Host Disease Following Matched Unrelated Donor Bone Marrow.
Intravenous Busulfan-Cyclophosphamide as a Preparative Regimen Before Allogeneic Hematopoietic Stem Cell Transplantation for Adult Patients with Acute.
Graft-Versus-Host Disease and Survival after Cord Blood Transplantation for Acute Leukemia: A Comparison of Japanese versus White Populations  Yachiyo.
Cytomegalovirus Glycoprotein B Genotype in Hematopoietic Stem Cell Transplant Patients from China  Xiaojin Wu, Ying Wang, Yang Xu, Depei Wu, Aining Sun,
Association of an Impaired Bone Marrow Microenvironment with Secondary Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation  Yuan.
Mark A. Schroeder, Jaebok Choi, Karl Staser, John F. DiPersio 
Single and Multiple Dose MultiStem (Multipotent Adult Progenitor Cell) Therapy Prophylaxis of Acute Graft-versus-Host Disease in Myeloablative Allogeneic.
KIR2DS4 and Its Variant KIR1D Are Associated with Acute Graft-versus-Host Disease, Cytomegalovirus, and Overall Survival after Sibling-Related HLA-Matched.
Allogeneic Stem Cell Transplantation for Patients with T315I BCR-ABL Mutated Chronic Myeloid Leukemia  Lan-Ping Xu, Zheng-Li Xu, Xiao-Hui Zhang, Huan.
IL-12hi Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ-Dependent and Fas- Supported Apoptosis of Alloreactive CD4+ T Cells and Inhibit Graft-Versus-Host.
Sympathectomy Protects Denervated Skin from Graft-Versus-Host Disease
Successful Treatment of Severe Acute Intestinal Graft-versus-Host Resistant to Systemic and Topical Steroids with Alemtuzumab  Marc Schnitzler, Jens Hasskarl,
Impact of Donor Type on Outcome after Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia  Scott R. Solomon, Connie A. Sizemore, Xu Zhang,
Epstein-Barr Virus–Related Post-Transplantation Lymphoproliferative Disorder after Unmanipulated Human Leukocyte Antigen Haploidentical Hematopoietic.
Human Herpesvirus-6B Reactivation Is a Risk Factor for Grades II to IV Acute Graft- versus-Host Disease after Hematopoietic Stem Cell Transplantation:
The Effects of Interleukin 10 and Interferon γ Cytokine Gene Polymorphisms on Survival after Autologous Bone Marrow Transplantation for Patients with.
Nonmalignant Late Effects in Survivors of Partially Matched Donor Hematopoietic Stem Cell Transplantation  Xiao-Dong Mo, Lan-Ping Xu, Dai-Hong Liu, Xiao-Hui.
Cytomegalovirus Glycoprotein B Genotype in Hematopoietic Stem Cell Transplant Patients from China  Xiaojin Wu, Ying Wang, Yang Xu, Depei Wu, Aining Sun,
Sabina Kersting, Leo F. Verdonck 
A Genetic Modifier of the Gut Microbiome Influences the Risk of Graft-versus-Host Disease and Bacteremia After Hematopoietic Stem Cell Transplantation 
Prophylactic Donor Lymphocyte Infusion (DLI) Followed by Minimal Residual Disease and Graft-versus-Host Disease–Guided Multiple DLIs Could Improve Outcomes.
Immunomodulation Effects of Mesenchymal Stromal Cells on Acute Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation  Ke Zhao, Rui Lou,
Treatment of Acute Leukemia with Unmanipulated HLA-Mismatched/Haploidentical Blood and Bone Marrow Transplantation  Xiao-Jun Huang, Dai-Hong Liu, Kai-Yan.
Blocking Activator Protein 1 Activity in Donor Cells Reduces Severity of Acute Graft- Versus-Host Disease through Reciprocal Regulation of IL-17–Producing.
Haploidentical Hematopoietic Stem Cell Transplantation without In Vitro T Cell Depletion for the Treatment of Philadelphia Chromosome–Positive Acute Lymphoblastic.
Impact of Pretransplantation Risk Factors on Post Transplantation Outcome of Patients with Acute Myeloid Leukemia in Remission after Haploidentical Hematopoietic.
Outcome and Minimal Residual Disease Monitoring in Patients with t(16;21) Acute Myelogenous Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation 
Impact of Ocular Chronic Graft-versus-Host Disease on Quality of Life
Recombinant Human Granulocyte Colony-Stimulating Factor Significantly Decreases the Expression of CXCR3 and CCR6 on T Cells and Preferentially Induces.
Lymphocyte Phenotype during Therapy for Acute Graft-versus-Host Disease: A Brief Report from BMT-CTN 0302  Javier Bolaños-Meade, Juan Wu, Brent R. Logan,
Role of the Mycobiome in Human Acute Graft-versus-Host Disease
Dynamic Detection of Anti–Human Leukocyte Antigen (HLA) Antibodies but not HLA-DP Loci Mismatches Can Predict Acute Graft-versus-Host Disease and Overall.
Trial in Progress: Gravitas-301, a Randomized, Double-Blind Phase 3 Study of Itacitinib or Placebo with Corticosteroids (CS) for the First-Line Treatment.
Helicobacter pylori Infection and Graft-versus-Host Disease
Sequential Intensified Conditioning and Tapering of Prophylactic Immunosuppressants for Graft-versus-Host Disease in Allogeneic Hematopoietic Stem Cell.
The Expression of Th17-Associated Cytokines in Human Acute Graft-versus-Host Disease  Yuejun Liu, Yifeng Cai, Lan Dai, Guanghua Chen, Xiao Ma, Ying Wang,
A Novel Strategy in Managing Post-Liver Transplant Acute Graft-Versus-Host-Disease: The New Era (T)Rojan Horse  Zeyad Kanaan, MD, William Tse, MD, FACP 
Dichotomous Role of Interferon-γ in Allogeneic Bone Marrow Transplant
Reconstitution of Natural Killer Cell Receptor Repertoires after Unmanipulated HLA- Mismatched/Haploidentical Blood and Marrow Transplantation: Analyses.
Low Risk of Chronic Graft-versus-Host Disease and Relapse Associated with T Cell– Depleted Peripheral Blood Stem Cell Transplantation for Acute Myelogenous.
Treatment of Severe Refractory Acute Graft-versus-Host Disease of the Gastrointestinal Tract with Campath-1H  Alessandro Busca, Franco Locatelli, Elisabetta.
Positive Results of Serum Galactomannan Assays and Pulmonary Computed Tomography Predict the Higher Response Rate of Empirical Antifungal Therapy in.
Persistence of host dendritic cells after transplantation is associated with graft-versus- host disease  Geoffrey W. Chan, Gullu Gorgun, Kenneth B. Miller,
Possible Association between Obesity and Posttransplantation Complications Including Infectious Diseases and Acute Graft-versus-Host Disease  Shigeo Fuji,
Haploidentical/Mismatched Hematopoietic Stem Cell Transplantation without In Vitro T Cell Depletion for T Cell Acute Lymphoblastic Leukemia  Yu Wang,
Diarrhea during the Conditioning Regimen Is Correlated with the Occurrence of Severe Acute Graft-versus-Host Disease through Systemic Release of Inflammatory.
Content Validity of the Lee Chronic Graft-versus-Host Disease Symptom Scale as Assessed by Cognitive Interviews  Emily C. Merkel, Sandra A. Mitchell,
Heterogeneity in Studies of Mesenchymal Stromal Cells to Treat or Prevent Graft- versus-Host Disease: A Scoping Review of the Evidence  Mina Rizk, Madeline.
Unrelated Stem Cell Transplantation after a Reduced Intensity Conditioning Regimen Containing High-Dose Thymoglobulin Leads to Controllable Graft-versus-Host.
John E. Levine, Sophie Paczesny, Stefanie Sarantopoulos 
High Incidence of Severe Acute Graft-Versus-Host Disease with Tacrolimus and Mycophenolate Mofetil in a Large Cohort of Related and Unrelated Allogeneic.
Blood and Marrow Transplant Handbook
Therapeutic Immunosuppression Concentrations on Day 0 and the Development of Acute Graft Versus Host Disease (GVHD) in Hematopoietic Stem Cell Transplantation.
Preengraftment Syndrome after Unrelated Cord Blood Transplant Is a Strong Predictor of Acute and Chronic Graft-versus-Host Disease  Haydar Frangoul, Li.
IFN-α Is Effective for Treatment of Minimal Residual Disease in Patients with Acute Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation:
Low Serum Levels of Total Rabbit-IgG Is Associated with Acute Graft-Versus-Host Disease after Unrelated Donor Hematopoietic Stem Cell Transplantation:
Mammen Chandy  Biology of Blood and Marrow Transplantation 
Monitoring Mixed Lineage Leukemia Expression May Help Identify Patients with Mixed Lineage Leukemia–Rearranged Acute Leukemia Who Are at High Risk of.
Treatment versus Transplant for Challenging Hematologic Disorders
Prospective Monitoring of Tumor Necrosis Factor α and Interferon γ to Predict the Onset of Acute and Chronic Graft-versus-Host Disease after Allogeneic.
Allogeneic Peripheral Blood Stem Cell Transplantation is a Promising and Safe Choice for the Treatment of Refractory/Relapsed Acute Myelogenous Leukemia,
Longitudinal Assessment of Morbidity and Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation: Retrospective Analysis of a.
Roles of CD28, CTLA4, and Inducible Costimulator in Acute Graft-versus-Host Disease in Mice  Jun Li, Kenrick Semple, Woong-Kyung Suh, Chen Liu, Fangping.
Increased Type 1 Immune Response in the Bone Marrow Immune Microenvironment of Patients with Poor Graft Function after Allogeneic Hematopoietic Stem Cell.
Mary Eapen  Biology of Blood and Marrow Transplantation 
Allogeneic Stem Cell Transplantation versus Tyrosine Kinase Inhibitors Combined with Chemotherapy in Patients with Philadelphia Chromosome–Positive Acute.
Presentation transcript:

Cytotoxic T Lymphocyte Antigen-4 Down-Regulates T Helper 1 Cells by Increasing Expression of Signal Transducer and Activator of Transcription 3 in Acute Graft-versus- Host Disease  Feng Zhu, Xiao-Min Zhong, Jianlin Qiao, Qiong Liu, Hai-Ying Sun, Wei Chen, Kai Zhao, Qing-Yun Wu, Jiang Cao, Wei Sang, Zhi-Ling Yan, Ling-Yu Zeng, Zhen-Yu Li, Kai-Lin Xu  Biology of Blood and Marrow Transplantation  Volume 22, Issue 2, Pages 212-219 (February 2016) DOI: 10.1016/j.bbmt.2015.11.003 Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 (A) CTLA-4 mRNA expression in patients with acute GVHD identified by RT-PCR. (B) CTLA-4 protein levels in patients with acute GVHD measured by Western blot analysis, 1-5, five patients with acute GVHD; M, marker. Biology of Blood and Marrow Transplantation 2016 22, 212-219DOI: (10.1016/j.bbmt.2015.11.003) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Expression of CTLA-4 in responders (R) with grade I-II and III-IV acute GVHD and healthy controls. (A) CTLA-4 expression in healthy controls and responders with acute GVHD before and after treatment measured by ELISA. (B) CTLA-4 expression in healthy controls and responders with acute GVHD before and after treatment measured by q-PCR. (C) CTLA-4 expression in healthy controls and responders with I-II and III-IV acute GVHD before and after treatment measured by ELISA. (D) CTLA-4 expression in healthy controls and responders with I-II and III-IV acute GVHD before and after treatment measured by q-PCR. Biology of Blood and Marrow Transplantation 2016 22, 212-219DOI: (10.1016/j.bbmt.2015.11.003) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Changes in STAT3 luciferase activity after up-regulation of CTLA-4. Biology of Blood and Marrow Transplantation 2016 22, 212-219DOI: (10.1016/j.bbmt.2015.11.003) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Changes in STAT3 and pSTAT3 protein expression after up-regulation of CTLA-4. Biology of Blood and Marrow Transplantation 2016 22, 212-219DOI: (10.1016/j.bbmt.2015.11.003) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 5 Changes in the degree of STAT3 phophorylation after up-regulation of CTLA-4. Biology of Blood and Marrow Transplantation 2016 22, 212-219DOI: (10.1016/j.bbmt.2015.11.003) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 6 Changes in proliferation of CD4+ T cells after up-regulation of CTLA-4. *P < .01, compared with the blank control group. #P < .05, compared with the FLAG group. Biology of Blood and Marrow Transplantation 2016 22, 212-219DOI: (10.1016/j.bbmt.2015.11.003) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 7 Changes in apoptosis of CD4+ T cells after up-regulation of CTLA-4. Biology of Blood and Marrow Transplantation 2016 22, 212-219DOI: (10.1016/j.bbmt.2015.11.003) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 8 Changes in secretion of IFN-γ (A), IL-4 (B), IL-17 (C), and IL-22 (D) after up-regulation of CTLA-4. Biology of Blood and Marrow Transplantation 2016 22, 212-219DOI: (10.1016/j.bbmt.2015.11.003) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions