Reconstitution of Normal Hepcidin Expression in Hfe-Deficient Mice After Liver Transplantation: A New Role of HFE in Kupffer Cells?  Ivana De Domenico, James P. Kushner  Gastroenterology  Volume 139, Issue 1, Pages 25-27 (July 2010) DOI: 10.1053/j.gastro.2010.05.020 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Regulation of hepcidin expression in hepatocytes. The expression of hepcidin is positively regulated by diferric transferrin (Tf(Fe2)), inflammation and by receptors for bone morphogenetic proteins (BMPs). Hepcidin is negatively regulated by anemia and hypoxia. The activation of cell-surface BMP receptors (BMPsR) by BMPs leads to the generation of phosphorylated receptor SMADs (SMADs-P). Membrane-bound hemojuvelin (HJV) functions as a co-receptor for BMPs, increasing the efficiency of the interaction of BMP with its receptor. Tf(Fe2) induces hepcidin via transferrin receptor-2 and HFE through an independent signal or by affecting signal transduction by the BMPsR. Gastroenterology 2010 139, 25-27DOI: (10.1053/j.gastro.2010.05.020) Copyright © 2010 AGA Institute Terms and Conditions