CASP8 mutations are associated with fewer CNAs and RAS family mutations. CASP8 mutations are associated with fewer CNAs and RAS family mutations. A, number.

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CASP8 mutations are associated with fewer CNAs and RAS family mutations. CASP8 mutations are associated with fewer CNAs and RAS family mutations. A, number of CNAs by CASP8 mutation status in OSCC. B, focal CNAs by CASP8 status in TCGA HNSCC samples. C, focal CNAs by CASP8 status in TCGA colorectal carcinoma (CRC) samples. Median values are shown by the bar. P values were calculated by Mann–Whitney test. D, number of samples with various CASP8 and RAS family genotypes. P values were calculated with Fisher's exact test. E, CASP8 genomic alterations identified in HNSCC cell lines. Mutations of unknown significance are indicated with an (*). F, frequency of tumor formation based on CASP8 mutation status. Mean values are shown by the bar. P value was calculated by Mann–Whitney test. G, difference in final tumor volume by CASP8 mutation status. P value was calculated by t test. Sample numbers are the same as in H. H, overall mouse survival by CASP8 mutation status. P value was calculated by log-rank test. Mouse tumor data are from Sano and colleagues (14). Curtis R. Pickering et al. Cancer Discovery 2013;3:770-781 ©2013 by American Association for Cancer Research