Reduced interorigin distance in BLM-deficient cells.

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Reduced interorigin distance in BLM-deficient cells. Reduced interorigin distance in BLM-deficient cells. A. Representative image and scheme of two adjacent replicons observed on individual DNA fibers. IdUrd was detected in red, and CldUrd was detected in green. The distance between the two origins (short double arrows) corresponds to the interorigin distance (long dashed double arrows). The central green CldUrd-labeled track results from the merge of the forks coming from the neighboring origins. White bar, 40 kb. B. Histogram showing interorigin distances in the transformed BLM-deficient (PSNG13) and in the complemented (PSNF5) cell lines. C. Histogram of the interorigin distances in the primary normal (GM00037) and primary untransformed BS cells (GM01492). Line, boundary for the statistical analysis. The Kolmogorov-Smirnov test was applied on the range of values indicated by the double-arrowed line in B and C. The total number of fibers analyzed was 92 for PSNF5, 52 for PSNG13, 50 for GM00037, and 44 for GM01492. V. Ashutosh Rao et al. Mol Cancer Res 2007;5:713-724 ©2007 by American Association for Cancer Research