Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase–dependent manner Tetsuya Adachi, MDa, Susan Stafford,

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Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase–dependent manner Tetsuya Adachi, MDa, Susan Stafford, BSb, Hiroyuki Kayaba, MDa, Junichi Chihara, MD, PhDa, Rafeul Alam, MD, PhDb Journal of Allergy and Clinical Immunology Volume 111, Issue 1, Pages 113-116 (January 2003) DOI: 10.1067/mai.2003.27 Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 A, Kinase activity of MLCK in eotaxin-stimulated eosinophils. Data are expressed as means ± SD (n = 3). *P < .05 versus without inhibitor; **P < .05 versus control (ANOVA). B, Effect of PD98059 and SB202190 on eotaxin-induced phosphorylation of MLCK in eosinophils. The upper blot was representative of 3 independent experiments. The lower panel represents the data from the densitometric analysis expressed as means ± SD (n = 3). *P < .05 versus eotaxin stimulation (ANOVA). Journal of Allergy and Clinical Immunology 2003 111, 113-116DOI: (10.1067/mai.2003.27) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 A, Phosphorylation of MLC in eosinophils. The upper blot was representative of 3 independent experiments. The lower panel represents the data from the densitometric analysis expressed as means ± SD (n = 3). **P < .05 versus no eotaxin. B, Effect of ML-7 on eotaxin-induced eosinophil chemotaxis. Data are expressed as means ± SD (n = 3). *P < .05 versus without inhibitor (ANOVA). Journal of Allergy and Clinical Immunology 2003 111, 113-116DOI: (10.1067/mai.2003.27) Copyright © 2003 Mosby, Inc. Terms and Conditions