Fig. 5. S. hominis A9 isolated from normal human skin produces unique lantibiotics. S. hominis A9 isolated from normal human skin produces unique lantibiotics.

Slides:

Advertisements

Similar presentations

Simultaneous determination of mushroom toxins α-amanitin, β-amanitin and muscarine in human urine by solid-phase extraction and ultra-high-performance.

Advertisements

Coenzyme A Glutathione Disulfide

Fig. 6. Sh-lantibiotics are commonly found on healthy human skin and synergize with a host AMP. Sh-lantibiotics are commonly found on healthy human skin.

Fig. 5. S. hominis A9 isolated from normal human skin produces unique lantibiotics. S. hominis A9 isolated from normal human skin produces unique lantibiotics.

Bacteroidales LPS inhibits TLR stimulation.

Marcel Zimmermann, Julian D. Hegemann, Xiulan Xie, Mohamed A. Marahiel

Fig. 3. Antimicrobial activity is detected in diverse strains of CoNS and not predictable at the species level. Antimicrobial activity is detected in diverse.

Volume 14, Issue 1, Pages (January 2007)

Bio-AMS enhances the activity of rifampicin and ethambutol in vitro

Fig. 4 CXCL4 potentiates TLR8-mediated activation of SSc pDCs.

Splenic CD169+ macrophages express a unique gene profile.

A, schematic presentation of fetuin-A domains.

Relative quantification of cis and trans PSP gp10040–42/47–52 variants

Analysis of a tryptic digest of subunit B12 by MALDI-TOF mass spectrometry. Analysis of a tryptic digest of subunit B12 by MALDI-TOF mass spectrometry.

Fig. 7. mRIPO therapy restricts tumor growth and produces antigen-specific antitumor immunity. mRIPO therapy restricts tumor growth and produces antigen-specific.

Fig. 3. Phenotypic characterization of FM2.5.

Fig. 6 Transmissibility of adiposity from humanized mice to germ-free recipients. Transmissibility of adiposity from humanized mice to germ-free recipients.

Fig. 6 In utero injection of inflammatory cytokines or adoptive transfer of activated T cells leads to pregnancy loss. In utero injection of inflammatory.

Aggregation kinetics of Aβ16–22 are unaffected by the presence of Aβ40

Consolidated Standards of Reporting Trials flow diagram of VRC trial

Fig. 2 AcPGP induces IL-8 and G-CSF release from human bronchial epithelial cells. AcPGP induces IL-8 and G-CSF release from human bronchial epithelial.

Cell viability tests. Cell viability tests. SEM images of (A) MC3T3-E1 cells and (B) MSCs on days 1, 3, and 5 of culture. (C) Survival rates of MC3T3-E1.

Fig. 2. Clinically actionable somatic genomic alterations in various tumor types. Clinically actionable somatic genomic alterations in various tumor types.

Fig. 5. Microarray analysis of tumors treated by dabrafenib, trametinib, or the combination of dabrafenib and trametinib with pmel-1 ACT or mock ACT. Microarray.

Fig. 3 ROC curves of mCCNA1 and mVIM assayed in esophageal cytology brushings from control normal-appearing GE junctions versus BE and EAC cases. ROC curves.

In vivo release of doxycycline hyclate from the GRS in a swine model

Fig. 5 Cell-free membrane cyclase assay confirms that candidate compounds are specific antagonists of hNPR1. Cell-free membrane cyclase assay confirms.

Fig. 5. Vitamin B12 supplementation in the host altered the transcriptome of P. acnes in the skin microbiota. Vitamin B12 supplementation in the host altered.

CD mediates metabolism and efflux of crystal-derived cholesterol

Crystal structure of DS-A. 02:01 ESO 9V and WT-A

Fig. 4 Rational therapeutic modulation of the tumor microenvironment sensitizes tumors to ICB. Rational therapeutic modulation of the tumor microenvironment.

Fig. 1. DEL-1 is expressed by human and mouse osteoclasts.

BMS blocks functional responses in primary immune cells driven by IFNα

Fig. 1. Detection of circulating tumor DNA in CRPC patients.

Histone H4 Is a Major Component of the Antimicrobial Action of Human Sebocytes Dong-Youn Lee, Chun-Ming Huang, Teruaki Nakatsuji, Diane Thiboutot, Sun-Ah.

The microchip-based drug delivery device and overview of study design

Fig. 3 Proteomic analysis and Western blot analysis of protein cargos of various EVs. Proteomic analysis and Western blot analysis of protein cargos of.

Fig. 2 PK dosing results. PK dosing results. (A) Plasma concentration of hPTH(1–34) versus time after release of 40-μg dose from implanted microchip device.

Fig. 3 Library of 8988 macrocycles screened against thrombin.

by Dezhi Kang, Baochen Shi, Marie C. Erfe, Noah Craft, and Huiying Li

Fig. 1. CCR5-TALEN and CCR5-megaTAL activity in T cells and comparison of NHEJ and HDR events in a TLR reporter line. CCR5-TALEN and CCR5-megaTAL activity.

LTB4 production is elevated in preclinical and clinical lymphedema

Fig. 6. Sh-lantibiotics are commonly found on healthy human skin and synergize with a host AMP. Sh-lantibiotics are commonly found on healthy human skin.

Fig. 4 Functional confirmation of genes associated with isopropanol tolerance in E. faecium. Functional confirmation of genes associated with isopropanol.

Fig. 8. Purkinje cell quantification and hearing threshold in NPC cats administered IC HPβCD. Purkinje cell quantification and hearing threshold in NPC.

Fig. 2 Viperin promotes methionine oxidation of KSHV helicase.

Fig. 3 Mmp-2−/− mice are protected from obesity and leptin resistance.

Fig. 3 Glycosylation profiling of MIH5 WT and Fc-silent variant using high-resolution native mass spectrometry. Glycosylation profiling of MIH5 WT and.

Fig. 1 Mmp-2 activity is increased in brains after HFD intake.

Fig. 5 Increased myometrial cell contractility in response to fetal T cells from preterm infants. Increased myometrial cell contractility in response to.

Fig. 4 BS-SEM images, ternary diagrams, and phase maps for the text and reverse sides of the TS. BS-SEM images, ternary diagrams, and phase maps for the.

Bio-AMS enhances the activity of rifampicin and ethambutol in vitro

In vivo prophylactic and therapeutic efficacy of C12G6 in mice

Fig. 1. Dysbiosis of the skin microbiome in AD is associated with S

Fig. 5. High burdens of AA signature mutations and predicted immunogenicity in Taiwan HCCs. High burdens of AA signature mutations and predicted immunogenicity.

Volume 15, Issue 10, Pages (October 2008)

Fig. 3. miR overexpression leads to increased cell proliferation as well as altered differentiation and metabolism in cardiomyocytes. miR

Fig. 2. Mechanism of PD-L1 down-regulation in NOD HSPCs.

Fig. 5 Clustering of the distal gut microbiome, the C

Fig. 2 Purification and characterization of the five RumC isoforms produced in vivo. Purification and characterization of the five RumC isoforms produced.

Fig. 3. Association between peak CTL019 expansion and response.

Fig. 2 NGS bisulfite sequencing assay of DNA methylation in esophageal biopsies. NGS bisulfite sequencing assay of DNA methylation in esophageal biopsies.

Fig. 1. Schematic description of whole-exome or targeted next-generation sequencing analyses. Schematic description of whole-exome or targeted next-generation.

Fig. 1 Isopropanol tolerance variation among E. faecium isolates.

Fig. 4 Gallium increases P. aeruginosa sensitivity to peroxides.

Fig. 6 Methionine oxidation catalyzed by viperin increases the stability and function of RNA helicase RIG-I. Methionine oxidation catalyzed by viperin.

Fig. 3 Postnatal assembly of the humanized gut microbiota.

Biochemical screen identifies LEDGF and HDGF2 as FACT-like factors

Fig. 4 Rotavirus induces the type I IFN pathway and release of ATP by tumor cells. Rotavirus induces the type I IFN pathway and release of ATP by tumor.

Fig. 6. Connectivity and mobility maps for Lesotho.

Presentation transcript:

Fig. 5. S. hominis A9 isolated from normal human skin produces unique lantibiotics. S. hominis A9 isolated from normal human skin produces unique lantibiotics. (A) Reverse-phase high-performance liquid chromatography elution profile of peptides purified from culture supernatant of S. hominis A9 strain. The insert is a radial diffusion activity against S. aureus from the indicated fractions. Molecular mass of fractions 30 and 32 was measured by MALDI-TOF mass spectrometry (MS) (fig. S4). (B) Amino acid sequence and predicted thioester bonds from the two lantibiotics purified from S. hominis A9. Dha, 2,3-didehydroalanine; Dhb, (Z)-2,3-didehydrobutyrine. (C) Organization of the gene cluster encoding Sh-lantibiotic precursors and lantibiotic biosynthetic genes in S. hominis A9. (D) List of lantibiotic-related genes, gene locus, and putative functions. (E) Effect of application of Sh-lantibiotics (0.5 nmol) or conditioned medium from S. hominis A9 (50 μl) on survival of S. aureus on pigskin. Data represent means ± SEM of four independent assays. **P < 0.01 by two-tailed independent t test. (F) Dose-response curves for the antimicrobial activity of Sh-lantibiotic-α and Sh-lantibiotic-β against S. hominis A9 strain. Data represent means ± SEM of triplicate assays. m/z, mass/charge ratio. Teruaki Nakatsuji et al., Sci Transl Med 2017;9:eaah4680 Copyright © 2017, American Association for the Advancement of Science