Fig. 5 The complex of antibody and dye can afford to target imaging in the NIR-II window. The complex of antibody and dye can afford to target imaging.

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Fig. 5 The complex of antibody and dye can afford to target imaging in the NIR-II window. The complex of antibody and dye can afford to target imaging in the NIR-II window. (A) Cell assay (lysate) test of the IR-783@Erbitux complex at both positive SCC cell and negative U87 cell. (B) SCC cell staining of IR-783@Erbitux described the reserved targeting ability of an antibody-based complex. DAPI, 4′,6-diamidino-2-phenylindole. (C) In vivo NIR-II imaging of an SCC tumor–bearing mouse with tail vein injection of the IR-783@Erbitux complex. (D) In vivo NIR-II imaging of an SCC tumor–bearing mouse with tail vein injection of free IR-783 under the same imaging conditions as the IR-783@Erbitux case. (E) NIR-II tumor signal of both IR-783@Erbitux and free IR-783 at increasing time points p.i. (significant difference between two groups was shown as *P < 0.05, **P < 0.01, and ***P < 0.001). Insets show tumors from different treatment cohorts with a lower z scale. (F) Ex vivo biodistribution of the IR-783@Erbitux complex at 168-hour time points p.i. MFI, mean fluorescence intensity. Rui Tian et al. Sci Adv 2019;5:eaaw0672 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).