Molecular Chaperones in Cellular Protein Folding: The Birth of a Field

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Molecular Chaperones in Cellular Protein Folding: The Birth of a Field Arthur L. Horwich Cell Volume 157, Issue 2, Pages 285-288 (April 2014) DOI: 10.1016/j.cell.2014.03.029 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Evidence of Protein Misfolding In Vivo: Formation of Inclusion Bodies Transmission electron micrograph showing formation of inclusion bodies (arrowed) in E.coli expressing a trp-proinsulin fusion protein (from Williams et al., 1982). Cell 2014 157, 285-288DOI: (10.1016/j.cell.2014.03.029) Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 2 A Transcriptional Response to Heat Stress Drosophila busckii salivary gland chromosome spreads, showing “puffing” of two regions following temperature shift of larvae from 25°C (top) to 30°C for 30 min (bottom) (from Ritossa, 1962). Cell 2014 157, 285-288DOI: (10.1016/j.cell.2014.03.029) Copyright © 2014 Elsevier Inc. Terms and Conditions