GK1 enhances the secretion of proinflammatory cytokines resulting from cognate interactions between activated DCs and T cells. GK1 enhances the secretion.

Slides:

Advertisements

Similar presentations

Fig. 1. Time course of total cells, protein concentration and cytokines in BAL fluid after LPS challenge. The number of total cells, neutrophils and macrophages.

Advertisements

LBH589 Enhances T Cell Activation In Vivo and Accelerates Graft-versus-Host Disease in Mice Dapeng Wang, Cristina Iclozan, Chen Liu, Changqing Xia, Claudio.

MD-2s fails to mediate LPS-dependent NF-κB activation and IL-8 secretion. MD-2s fails to mediate LPS-dependent NF-κB activation and IL-8 secretion. A,

PVSRIPO-mediated APC activation occurs in immunosuppressive conditions

LV envelope is responsible for DC activation.

A, RT-qPCR of ROR1 mRNA expression in B-CLL cells and a panel of human and rhesus macaque tissues. A, RT-qPCR of ROR1 mRNA expression in B-CLL cells and.

Maturation, Ag presentation capacity, and IL-12 production of DCs

PD‐L1 silencing in antigen presenting DCs results in hyperactivated pro‐inflammatory TCRhigh CD8+ T cells. PD‐L1 silencing in antigen presenting DCs results.

Effect of OPN on apoptosis of DCs

Jethe O. F. Nunes, PhD, Juliana de Souza Apostolico, MSc, David A. G

DCs induce the proliferation of autologous T cells.

Response of monocytes to hY4 delivery and cytokine levels in CLL serum

Effects of IL-1α on the composition of infiltrating proinflammatory cells in inflamed colons during DSS-induced colitis. Effects of IL-1α on the composition.

Assessment of CD40L expression and function for diagnosis of X-linked hyper-IgM syndrome (XL-HIGM). Assessment of CD40L expression and function for diagnosis.

Flow cytometry analysis of TNF-β- and IL-10-producing CD33+ cells.

Viral fusion is required for DC activation.

Volume 27, Issue 1, Pages (July 2007)

Role of TLR signaling in hY4-induced changes and effects of TLR inhibition. Role of TLR signaling in hY4-induced changes and effects of TLR inhibition.

Fig. 5 Extended local release of R848 increases the number of innate and adaptive antitumor immune cells and cytokines. Extended local release of R848.

Hematopoietic potential of HEP from patient-specific iPSC may be reduced. Hematopoietic potential of HEP from patient-specific iPSC may be reduced. (A)

Determination of IL-5+ and IL-6+ cells in the lamina propria of the small intestines of mice receiving L. casei administration. Determination of IL-5+

Increased proinflammatory cytokine production is dependent on both the training interval and the resting time. Increased proinflammatory cytokine production.

Effects of TNF-α, IL-6, and IL-1β on 3T3-L1 adipocyte differentiation

Contribution of individual serovars within serogroups isolated in the United States in Contribution of individual serovars within serogroups isolated.

Anti-inflammatory cytokine production is increased in trained monocytes. Anti-inflammatory cytokine production is increased in trained monocytes. (A) IL-10.

ROS production is a component of trained immunity for some stimuli.

Reproducibility of LPA results for cryopreserved PBMC after variable periods of storage in liquid nitrogen. Reproducibility of LPA results for cryopreserved.

Viability and viable cell recovery of cryopreserved PBMC after variable periods of storage in liquid nitrogen. Viability and viable cell recovery of cryopreserved.

NK cell immune evasion occurs through loss of TNF pathway members.

Trained immunity induction of glycolysis.

Fig. 3 BMS blocks functional responses in primary immune cells driven by IL-23 and IL-12. BMS blocks functional responses in primary immune.

Cytokine synthesis from mononuclear cells.

Antibody titers against surface antigens of B

Trained immunity effects on cell morphology and numbers.

Immunization regimens that include a GLA-SE-formulated protein vaccine generate memory CD4 T cells. Immunization regimens that include a GLA-SE-formulated.

Comparison of OPN production by mature DCs and activated macrophages.

OPN mediates maturation from immature DCs to mature DCs

by Yuwen Zhu, Sheng Yao, Mathew M

NK activity in healthy donors (n=51) and patients with FRH upon recurrence (n=28) and remission (n=23). NK activity in healthy donors (n=51) and patients.

Flow cytometry analysis of intracellular cytokine expression in control PBMC (left set of panels) and following either PMA-ionomycin activation (middle.

Dilution of anti-C6 monoclonal antibody shows the broader linear range of the Multiplex assay in comparison to standard ELISA. Shown is the dilution of.

Supernatants of the positive proliferative responses indicated in Table 1 were analyzed for the presence of IFNγ, tumor necrosis factor-α, IL-2, IL-4,

Reproducibility of CD4+ and CD8+ T-cell enumeration with cryopreserved PBMC after variable periods of storage in liquid nitrogen. Reproducibility of CD4+

Antibody titers against surface antigens of M

Combined inhibition of Wee1 and PARP causes persistent radiation-induced DNA damage. Combined inhibition of Wee1 and PARP causes persistent radiation-induced.

Tregs preferentially regulate TH2 cytokines in skin.

Relation between the total white blood count and the absolute lymphocyte count prior to the first vaccination and the response to vaccination. Relation.

DAC treatment alters immune cell composition and enhances cytokine production in the peritoneal lavage. DAC treatment alters immune cell composition and.

B- and T-cell activity induced by immunization.

LPS inhibits polyI:C-induced proinflammatory cytokines in human DCs

TNA associated with FD3-specific Abs.

Group-averaged IL-10 levels (in pg/ml) from the Luminex assay for control, CFS with FM, and CFS without FM groups. Group-averaged IL-10 levels (in pg/ml)

Cytokine expression induced by ligated-intestinal-loop assay using RT-PCR. Cytokine expression induced by ligated-intestinal-loop assay using RT-PCR. PCR.

Long-lived antibody-secreting cells in the bone marrow, induced by PfCelTOS vaccines containing various adjuvant formulations with emulsion doses of 0.02%

Long-lived antibody-secreting cells in the bone marrow, induced by PfCelTOS vaccines containing various adjuvant formulations with emulsion doses of 0.5%

Typical pattern of the degranulation of NK cells from a healthy donor (upper row) and a patient with FRH in recurrence (middle row) and in remission (lower.

Time to culling for mastitis among J5 vaccinates and controls

Antigen-specific cytokine production detected by multiplex bead assay (Luminex) 3 weeks after the 3rd immunization. Antigen-specific cytokine production.

Antigen-specific cytokine-producing cells (IFN-γ and IL-5) detected by ELISPOT assay 3 weeks after the 3rd immunization. Antigen-specific cytokine-producing.

Representative results of immunofixation electrophoresis (IFE) of cryoglobulins. Representative results of immunofixation electrophoresis (IFE) of cryoglobulins.

Anti-PT IgG results from 227 patients with coughs of unknown etiology who reported the severity of cough on a scale from 0 to 10. Anti-PT IgG results from.

Furin-dependent infection following ECM attachment.

Lkt antibody titers of vaccinated and control groups of BHS

Schematic presentation of the major domains of Alps, the signal peptide (S), the N-terminal region (N), the repeat region (R), and the C-terminal region.

Time to culling for all reasons among J5 vaccinates and controls

OPN production by immature DCs and mature DCs treated with PAMPs

IgA and IgG antibodies reactive to TT, alpha-toxin, and BSA in two groups of chickens 2 weeks after oral gavage with probiotics or with PBS. The two groups.

Distribution of responses to vaccine antigens in the culture-positive individual group and the control group. Distribution of responses to vaccine antigens.

Lack of innate immune cell and receptor triggering by Adjuplex.

Variability between laboratories in titer estimations (expressed as GCV on the y axis) tends to be higher for samples in low measurement ranges and to.

Presentation transcript:

GK1 enhances the secretion of proinflammatory cytokines resulting from cognate interactions between activated DCs and T cells. GK1 enhances the secretion of proinflammatory cytokines resulting from cognate interactions between activated DCs and T cells. Supernatants from the cocultures of LPS-treated DCs or LPS- and GK1-treated DCs obtained from the experiment whose results are shown in Fig. 2B were recovered, and the cytokine levels were determined by flow cytometry with a cytometric bead array mouse inflammation kit (BD Biosciences). The results represent the mean of two independent experiments. René Segura-Velázquez et al. Clin. Vaccine Immunol. 2009; doi:10.1128/CVI.00106-09