Marcelo Cypel, MD, MSc, Jonathan C

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Marcelo Cypel, MD, MSc, Jonathan C

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Presentation transcript:

Experience with the first 50 ex vivo lung perfusions in clinical transplantation Marcelo Cypel, MD, MSc, Jonathan C. Yeung, MD, PhD, Tiago Machuca, MD, Manyin Chen, MD, Lianne G. Singer, MD, Kazuhiro Yasufuku, MD, PhD, Marc de Perrot, MD, MSc, Andrew Pierre, MD, MSc, Thomas K. Waddell, MD, PhD, Shaf Keshavjee, MD, MSc The Journal of Thoracic and Cardiovascular Surgery Volume 144, Issue 5, Pages 1200-1207 (November 2012) DOI: 10.1016/j.jtcvs.2012.08.009 Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Study diagram. ECLS, Extracorporeal life support; EVLP, ex vivo lung perfusion; Tx, transplantation. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 1200-1207DOI: (10.1016/j.jtcvs.2012.08.009) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Lung function during EVLP in lungs used (n = 50) and rejected (n = 8) for transplantation. Gas exchange, peak airway pressure, and dynamic compliance were significantly better in lungs used after EVLP compared with lungs that were rejected. No differences were observed in pulmonary artery pressures. PAP, Pulmonary artery pressure; PawP, peak airway pressure; P/F, Pao2/Fio2; EVLP, ex vivo lung perfusion. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 1200-1207DOI: (10.1016/j.jtcvs.2012.08.009) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Proportional survival of EVLP and conventional transplants. A, No differences were observed in the 2 groups (P = .69). B, No differences were observed in the survival of recipients receiving lungs from either donor types (BDDs or DCDs) after EVLP (P = .71). C, Recipients who received EVLP lungs in which the donor P/F ratio was less than 300 mm Hg had similar outcomes compared with recipients who received donor lungs with a P/F ratio more than 300 mm Hg (P = .78). BDD, Brain death donor; DCD, cardiac death donor; EVLP, ex vivo lung perfusion; LTx, lung transplantation. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 1200-1207DOI: (10.1016/j.jtcvs.2012.08.009) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions