Volume 18, Issue 9, Pages 821-833 (September 2019) Self-managed, computerised speech and language therapy for patients with chronic aphasia post-stroke compared with usual care or attention control (Big CACTUS): a multicentre, single-blinded, randomised controlled trial  Rebecca Palmer, PhD, Munyaradzi Dimairo, PhD, Prof Cindy Cooper, PhD, Prof Pam Enderby, PhD, Prof Marian Brady, PhD, Prof Audrey Bowen, PhD, Nicholas Latimer, PhD, Prof Steven Julious, PhD, Elizabeth Cross, MA, Abualbishr Alshreef, MSc, Madeleine Harrison, MPH, Ellen Bradley, MA, Helen Witts, BMedSci, Tim Chater, BSc  The Lancet Neurology  Volume 18, Issue 9, Pages 821-833 (September 2019) DOI: 10.1016/S1474-4422(19)30192-9 Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 1 Trial profile CSLT=computerised speech language therapy. *Deaths before 6 months excluded in all clinical effectiveness analysis but included in safety analysis. † Participants included in the modified intention-to-treat primary analysis set. The Lancet Neurology 2019 18, 821-833DOI: (10.1016/S1474-4422(19)30192-9) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 2 Mean response profile of participants for the co-primary and key secondary outcomes COAST=Communication Outcomes After Stroke. CSLT=computerised speech language therapy. TOMs=Therapy Outcome Measures. The Lancet Neurology 2019 18, 821-833DOI: (10.1016/S1474-4422(19)30192-9) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions