A) Arterial partial oxygen pressure (PaO2) and b) PaO2/inspired oxygen fraction (FIO2) ratio as a function of FIO2 in lungs simulated to have only shunt.

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a) Arterial partial oxygen pressure (PaO2) and b) PaO2/inspired oxygen fraction (FIO2) ratio as a function of FIO2 in lungs simulated to have only shunt and no alveolar ventilation/perfusion ratio inequality. a) Arterial partial oxygen pressure (PaO2) and b) PaO2/inspired oxygen fraction (FIO2) ratio as a function of FIO2 in lungs simulated to have only shunt and no alveolar ventilation/perfusion ratio inequality. PaO2/FIO2 steadily increases with FIO2 when shunt is absent or small, falls and then rises with FIO2 when shunt is moderate, and steadily falls when shunt is large. Peter D. Wagner Eur Respir J 2015;45:227-243 ©2015 by European Respiratory Society