Fig. 6 TNF-α neutralization prevents ZIKV-induced seizures in mice.

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Fig. 6 TNF-α neutralization prevents ZIKV-induced seizures in mice. TNF-α neutralization prevents ZIKV-induced seizures in mice. (A) Percentage of animals with seizures in each litter at 12 dpi in ZIKV-infected mice treated intraperitoneally with phosphate-buffered saline (PBS) (58 of 67 mice had seizures), NAC (19 of 22 mice had seizures), or infliximab (32 of 72 mice had seizures). No events were observed in 48 mock-infected mice. (B and C) Time to first seizure for male (B) (n = 10 mock + PBS, n = 7 ZIKV + PBS, and n = 7 ZIKV + Inflix) and female (C) (n = 5 mock + PBS, n = 6 ZIKV + PBS, and n = 4 ZIKV + Inflix) mice after an acute intraperitoneal injection of PTZ at 55 to 65 dpi. (D and E) Number of seizures for male (D) (n = 8 mock + PBS, n = 5 ZIKV + PBS, and n = 5 ZIKV + Inflix) and female (E) (n = 6 mock + PBS, n = 7 ZIKV + PBS, and n = 4 ZIKV + Inflix) mice after an intraperitoneal injection of PTZ at 55 to 65 dpi. (F and G) Latency to fall in the rotarod for male (F) (n = 10 mock + PBS, n = 7 ZIKV + PBS, and n = 8 ZIKV + Inflix) and female (G) (n = 9 per group) mice at 55 to 65 dpi. (H and I) Percentage of exploration toward familiar and novel objects in the NOR test performed in male (H) (n = 9 mock + PBS, n = 8 ZIKV + PBS, and n = 16 ZIKV + Inflix) and female (I) (n = 10 mock + PBS, n = 10 ZIKV + PBS, and n = 12 ZIKV + Inflix) mice at 55 to 65 dpi. In (A), *P = 0.0034, one-way ANOVA, followed by Dunnett’s test, ZIKV + Inflix versus ZIKV + PBS; in (B), *P = 0.0209 and **P = 0.0067; in (G), *P = 0.0375, one-way ANOVA, followed by Tukey test; in (H), *P = 0.0125; in (I), *P = 0.0024, one-sample Student’s t test compared to a fixed value of 50. Isis Nem de Oliveira Souza et al., Sci Transl Med 2018;10:eaar2749 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works