Proportions of the social isolation—AMI and stroke excess risk mediated by biological, behavioural, socioeconomic and health-related factors. Proportions of the social isolation—AMI and stroke excess risk mediated by biological, behavioural, socioeconomic and health-related factors. AMI, acute myocardial infarction; PERM, percentage of excess risk mediated. Christian Hakulinen et al. Heart 2018;104:1536-1542 Copyright © BMJ Publishing Group Ltd & British Cardiovascular Society. All rights reserved.