Schematic representation of the interaction between amphotericin B and cholesterol in a phospholipid bilayer. Schematic representation of the interaction.

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Schematic representation of the interaction between amphotericin B and cholesterol in a phospholipid bilayer. Schematic representation of the interaction between amphotericin B and cholesterol in a phospholipid bilayer. (A) The conducting pore is formed by the end-to-end union of two wells or half pores. Adapted from reference 21 with permission of the publisher. (B) Molecular orientation in an amphotericin B-cholesterol pore. The dotted lines between the hydrocarbon chains of phospholipids represent short-range London-van der Waals forces. The dashed lines represent hydrogen bonds formed between amphotericin B and cholesterol molecules. Mahmoud A. Ghannoum, and Louis B. Rice Clin. Microbiol. Rev. 1999; doi:10.1128/CMR.12.4.501