Advances in basic and clinical immunology in 2016

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Presentation transcript:

Advances in basic and clinical immunology in 2016 Javier Chinen, MD, PhD, Yousef R. Badran, MD, Raif S. Geha, MD, Janet S. Chou, MD, Ari J. Fried, MD  Journal of Allergy and Clinical Immunology  Volume 140, Issue 4, Pages 959-973 (October 2017) DOI: 10.1016/j.jaci.2017.07.023 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Schematic representation of whole-exome sequencing (WES) and whole-genome sequencing (WGS). Genomic DNA is fragmented and amplified, and then a “library” is made of these DNA fragments and fused with adaptors to facilitate sequencing. In WES the coding exome is enriched. Differences in the patient's DNA sequence and the reference genome are identified and analyzed for possible clinical significance. TSS, Transcription start site; UTR, untranslated region. Reproduced with permission from Meyts I, Bosch B, Bolze A, Boisson B, Itan Y, Belkadi A, et al. Exome and genome sequencing for inborn errors of immunity. J Allergy Clin Immunol 2016;138:957-69. Journal of Allergy and Clinical Immunology 2017 140, 959-973DOI: (10.1016/j.jaci.2017.07.023) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions