A method for the objective assessment of airway artery dimensions (the AA method) to diagnose bronchiectasis. A method for the objective assessment of.

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A method for the objective assessment of airway artery dimensions (the AA method) to diagnose bronchiectasis. A method for the objective assessment of airway artery dimensions (the AA method) to diagnose bronchiectasis. Boxplots show the ratio between the outer edge of the airway (Aout) and the adjacent artery (A). Aout/A ratios are shown for four consecutive groups: control (n=23); first and second cystic fibrosis-computed tomography (CF-CT1 (n=12) and CF-CT2 (n=12), respectively); and CT scans in a cross sectional cohort including patients aged 6–16 years (CF 6–16) (n=11). In total, 11 262 AA pairs were measured. Aout/A ratios are plotted against segmental generation (1 is the first segmental bronchus up to the 12th airway generation peripheral from the segmental bronchus). Control subjects were age-matched for CF patients. Median ages are 2 years, 3.9 years and 11 years for CF-CT1, CF-CT2 and CF 6–16, respectively. Boxes show median (horizontal line), interquartile range (box) and 1.5× interquartile range (whiskers). Outliers are shown as points. Note that for controls, Aout/A ratios were constant, whereas for each of the three CF groups an increasing and significant difference could be found in Aout/A ratio between the CF and control group from generation 2 to generation 5 (all p≤0.02). Furthermore, the difference between CF and controls was bigger for the oldest CF patients. Note that for generation 9 and higher, no more airway artery pairs were visible on the scans for control subjects, while airway artery pairs were still visible on the CT scans of CF patients [34, 35]. Reproduced and modified from [34]. Harm A.W.M Tiddens et al. Eur Respir Rev 2018;27:170097 ©2018 by European Respiratory Society