Gengo Sunagawa, MD, Nicole Byram, BS, Jamshid H

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The Contribution to Hemodynamics Even at Very Low Pump Speeds in the HVAD Gengo Sunagawa, MD, Nicole Byram, BS, Jamshid H. Karimov, MD, PhD, David J. Horvath, MSME, Nader Moazami, MD, Randall C. Starling, MD, MPH, Kiyotaka Fukamachi, MD, PhD The Annals of Thoracic Surgery Volume 101, Issue 6, Pages 2260-2264 (June 2016) DOI: 10.1016/j.athoracsur.2015.12.002 Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 HeartWare HVAD and pneumatic pump circulatory loop used in the in vitro tests. (F1 = flow probe 1 (total flow); F2 = flow probe 2 (HVAD flow); R = systemic resistor.) The Annals of Thoracic Surgery 2016 101, 2260-2264DOI: (10.1016/j.athoracsur.2015.12.002) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Steady-state pressure-flow relationships. These measurements, which include obtained data, are shown for the various pump speeds tested. The Annals of Thoracic Surgery 2016 101, 2260-2264DOI: (10.1016/j.athoracsur.2015.12.002) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Pump flows and pressure rise measurements in a mock loop. Flow and pressure data were compared in steady-state, normal heart function, and heart failure conditions. (A) At 3,000 rpm. (B) At 1,800 rpm. (R2 = coefficient of determination.) The Annals of Thoracic Surgery 2016 101, 2260-2264DOI: (10.1016/j.athoracsur.2015.12.002) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Pump flow. (A) Pump flows in normal heart function were compared between 1,800 rpm LVAD support and 3,000 rpm LVAD support. (B) Pump flows at 1,800 rpm LVAD support were compared between normal heart function and heart failure conditions. The Annals of Thoracic Surgery 2016 101, 2260-2264DOI: (10.1016/j.athoracsur.2015.12.002) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Pressure and flow. (A) Hemodynamics (aortic pressure [AoP] and pump flow) in normal heart function were compared between 1,800 rpm LVAD support and no LVAD support (LVAD clamped). (B) Hemodynamics (AoP and pump flow) in heart failure were compared between 1,800 rpm LVAD support and no LVAD support (LVAD clamped). The Annals of Thoracic Surgery 2016 101, 2260-2264DOI: (10.1016/j.athoracsur.2015.12.002) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions