Reduced β-catenin and cyclin D1 expression and increased apoptosis in lactating mammary gland epithelia of DDTg mice. Reduced β-catenin and cyclin D1 expression.

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Reduced β-catenin and cyclin D1 expression and increased apoptosis in lactating mammary gland epithelia of DDTg mice. Reduced β-catenin and cyclin D1 expression and increased apoptosis in lactating mammary gland epithelia of DDTg mice. (A and B) Sections were immunostained with an anti-β–catenin antibody (red staining), and counterstained with hematoxylin (blue staining). (A) High levels of cytoplasmic β-catenin (arrowheads) were observed in normal epithelia of lactating mammary gland at 2 d postpartum. (B) The mammary gland of DDTg mice at 2 d postpartum showed reduced levels of β-catenin. (C and D) Immunohistochemical staining with an anti-cyclin D1 antibody revealed a reduced level of cyclin D1 expression in the epithelia of lactating mammary gland at 2 d postpartum. (C) The lactating mammary gland of a control mouse showed intense and uniform staining. (D) Mammary epithelia of DDTg mice showed reduced staining and, in some areas (indicated by arrowheads), lack of staining above background levels. (E) Protein lysates from control and DDTg mammary gland at 17.5 dpc were immunostained with (left) anti-myc antibody to detect transgenic expression of MT–Axin, (center) anti-K14 (50 kD) antibody, serving as a control of the epithelial cell content of the mammary gland, and (right) anti-cyclin D1 antibody. The level of cyclin D1 (36 kD) was ninefold reduced in the DDTg mammary epithelia compared with the control, after normalization for K14 levels. The positions of protein molecular weight markers are indicated at the left. Arrowheads indicate the presence of the specific protein bands and the asterisk indicates nonspecific bands. (F and G) TUNEL staining of control (F) and DDTg (G) mouse mammary glands at 2 d postpartum. The epithelia of DDTg lactating mammary gland displayed increased numbers of apoptotic cells. Bars: (A and B) 62.5 μm; (C, D, F, and G) 125 μm. Wei Hsu et al. J Cell Biol 2001;155:1055-1064 © 2001 Rockefeller University Press