David R. J. Glenn, M. R. C. O. G. , Carmel M. McVicar, Ph. D

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Sildenafil citrate improves sperm motility but causes a premature acrosome reaction in vitro  David R.J. Glenn, M.R.C.O.G., Carmel M. McVicar, Ph.D., Neil McClure, F.R.C.O.G., Sheena E.M. Lewis, Ph.D.  Fertility and Sterility  Volume 87, Issue 5, Pages 1064-1070 (May 2007) DOI: 10.1016/j.fertnstert.2006.11.017 Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 The effects of sildenafil on progressive motility of human sperm ▴ control sperm ° sperm incubated in the presence of 0.67 μM sildenafil citrate Values are means for 22 samples; P<.001. Glenn. Sildenafil citrate accelerates sperm function. Fertil Steril 2007. Fertility and Sterility 2007 87, 1064-1070DOI: (10.1016/j.fertnstert.2006.11.017) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 The effect of sildenafil citrate on the velocity of human sperm ▴ control sperm ° sperm incubated in the presence of 0.67 μM sildenafil citrate Values are means for 22 samples; P<.001. Glenn. Sildenafil citrate accelerates sperm function. Fertil Steril 2007. Fertility and Sterility 2007 87, 1064-1070DOI: (10.1016/j.fertnstert.2006.11.017) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 The effects of sildenafil citrate on sperm acrosome reactions ■ control sperm ■ sperm incubated in the presence of 0.67 μM sildenafil citrate Values are means ± SE for 33 samples.*P<.05, **P<.01, show significant differences with Student’s t-test between control samples and those exposed to 0.67 μM of sildenafil citrate. Glenn. Sildenafil citrate accelerates sperm function. Fertil Steril 2007. Fertility and Sterility 2007 87, 1064-1070DOI: (10.1016/j.fertnstert.2006.11.017) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions