Fig. 1 Blood nicotine levels after escalation of nicotine intake.

Slides:

Advertisements

Similar presentations

Fig. 5 Correlation of RNA expression and protein abundance.

Advertisements

Fig. 2 Transport properties of a BP transistor at low temperature.

Fig. 4 Ballistic simulation of BP FETs.

Fig. 3 FM MnBi2Te4 bulk. FM MnBi2Te4 bulk. Crystal structure (A) and band structure (B) of the FM bulk. (C) Zoom-in band structures along the out-of-plane.

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Vibrational spectra of medieval human bones (Leopoli-Cencelle, Italy)

Fig. 3 Oil, gas, and FP water variations with time.

Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.

Fig. 1 Map of water stress and shale plays.

Fig. 1 Examples of experimental stimuli and behavioral performance.

Fig. 2 Some examples of weekly forecasts (the number of the forecasts are reported on Table 1). Some examples of weekly forecasts (the number of the forecasts.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

HT synthesis of boronic acids using the building block approach

Fig. 6 Comparison of properties of water models.

Fig. 1 Mean and median RCR (Relative Citation Ratio) of Roadmap Epigenomics Program research articles for each year. Mean and median RCR (Relative Citation.

Fig. 2 Influence of the Roadmap Epigenomics Program on the field of epigenomics research. Influence of the Roadmap Epigenomics Program on the field of.

Fig. 2 Reference-fixing experiment, results.

Fig. 4 Latency of CsLoc during testing.

Fig. 3 Scan rate effects on the layer edge current.

Fig. 1 Experimental apparatus used to train and test free-flying bees on their capacity to learn addition and subtraction. Experimental apparatus used.

Fig. 3 Rotation experiment, setup.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Fig. 5 Structural photocycle for DmCry.

Fig. 1 Proportions of normative beliefs by exchange condition, level of redistribution (0 = random, one-card, and two-card exchange), and outcome as winner.

Fig. 1 Distribution of total and fake news shares.

Fig. 3 Photon number statistics resulting from Fock state |l, S − l〉 interference. Photon number statistics resulting from Fock state |l, S − l〉 interference.

Fig. 2 2D QWs of different propagation lengths.

Electronic structure of the oligomer (n = 8) at the UB3LYP/6-31G

Fig. 4 DFT ωB97x/def2-TZVPP atomic charges on the sulfur atom of substituted thioaldehyde and AIMNet prediction with a different number of iterative passes.

NicA2-J1 prevents nicotine addiction–like behavior during withdrawal

Fig. 3 ET dynamics on the control and treatment watersheds during the pretreatment and treatment periods. ET dynamics on the control and treatment watersheds.

Fig. 1 Histograms of the number of first messages received by men and women in each of our four cities. Histograms of the number of first messages received.

Fig. 5 Schematic phase diagrams of Ising spin systems and Mott transition systems. Schematic phase diagrams of Ising spin systems and Mott transition systems.

Fig. 4 OER performance of ACoO3 (A = Ca, Sr) in alkaline solutions with different pH. OER performance of ACoO3 (A = Ca, Sr) in alkaline solutions with.

Fig. 1 Average contribution (million metric tons) of seafood-producing sectors, 2009–2014. Average contribution (million metric tons) of seafood-producing.

Fig. 4 The mechanical performances of thermally stable click-ionogels.

Fig. 4 Evolution of fraction of sickled RBCs under hypoxia.

Fig. 2 Magnetic properties of FGT/Pt bilayer.

Fig. 3 Characterization of the current-induced effective fields.

Fig. 3 Production of protein and Fe(II) at the end of growth correlated with increasing concentrations of ferrihydrite in the media that contained 0.2.

Fig. 2 Schematic drawings of Göbekli Tepe skulls.

Fig. 4 SPICE simulation of stochasticity.

Fig. 2 NH3, NOx, SO2, and NMVOC emission changes triggered by the JJJ clean air policy. NH3, NOx, SO2, and NMVOC emission changes triggered by the JJJ.

Fig. 1 Size fractions of MPPs in different fertilizers.

Fig. 2 Sources of plastic waste imports into China in 2016 and cumulative plastic waste export tonnage (in million MT) in 1988–2016. Sources of plastic.

Fig. 2 Top 10 countries, ecoregions, conservation hotspots, and KBAs with the largest area of restoration hotspots. Top 10 countries, ecoregions, conservation.

Fig. 4 Relationships between light and economic parameters.

Fig. 5 Comparison of the liquid products generated from photocatalytic CO2 reduction reactions (CO2RR) and CO reduction reactions (CORR) on two catalysts.

Schematic of the proposed brain-controlled assistive hearing device

Fig. 5 Skull 1: Tentative reconstruction.

Fig. 2 News volume and median article similarity as predictors of public attention in the domain Drones. News volume and median article similarity as predictors.

Fig. 1 Location of the Jirzankal Cemetery.

Fig. 4 CO2 emission changes triggered by the JJJ clean air policy.

Fig. 3 Earthquake seismic waves detected in Berkeley.

Multiplexed four- and eight-channel devices for rapid processing

Fig. 3 Comparisons of NDVI trends over the globally vegetated areas from 1982 to Comparisons of NDVI trends over the globally vegetated areas from.

Fig. 1 Effects of experimental warming on nematode communities across the gradient of plant species richness. Effects of experimental warming on nematode.

Fig. 1 Schematic depiction of a paradigm for rapid and guided discovery of materials through iterative combination of ML with HiTp experimentation. Schematic.

Fig. 6 NicA2-J1 prevents nicotine- and stress-induced reinstatement after extinguished nicotine intake. NicA2-J1 prevents nicotine- and stress-induced.

Fig. 4 Mapping of abundance of the most dominant bacterial and archaeal phyla across France. Mapping of abundance of the most dominant bacterial and archaeal.

Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.

Fig. 4 Single-particle contact angle measurements.

Fig. 3 Performance of the generative model G, with and without stack-augmented memory. Performance of the generative model G, with and without stack-augmented.

Fig. 4 Behavior of resistance peak near density nm = 5.

Fig. 2 Comparison between the different reflective metasurface proposals when θi = 0° and θr = 70°. Comparison between the different reflective metasurface.

Fig. 1 Overview of amber clast with synchrotron x-ray μCT image of articulated snake skeleton (DIP-S-0907). Overview of amber clast with synchrotron x-ray.

Fig. 5 NicA2-J1 reduces compulsive-like responding for nicotine in dependent rats. NicA2-J1 reduces compulsive-like responding for nicotine in dependent.

Fig. 4 Effects of individual picosecond and microsecond pulses.

Fig. 3 Calculated electronic structure of ZrCoBi.

Fig. 2 Time series of secularization versus GDP per capita, from four illustrative countries, over the 20th century. Time series of secularization versus.

Presentation transcript:

Fig. 1 Blood nicotine levels after escalation of nicotine intake. Blood nicotine levels after escalation of nicotine intake. (A) Detailed timeline of the experiments. (B) After the last session of escalation of nicotine intake, blood nicotine levels were detected in rats that were pretreated with NicA2-J1 (2 mg/kg) (red circles) and rats that were pretreated with PBS (blue circles). Student’s t test showed no difference in blood nicotine levels between groups (t = 1.15, df = 14, P > 0.05). (C) At the termination of escalation of nicotine intake, rats that were pretreated with NicA2-J1 (10 mg/kg) exhibited nearly undetectable levels of nicotine in blood compared with the PBS-pretreated group (Student’s t test; t = 4.198, df = 14, P < 0.001). **P < 0.01. Marsida Kallupi et al. Sci Adv 2018;4:eaat4751 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).