Modeling asthma exacerbations through lung function in children

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Presentation transcript:

Modeling asthma exacerbations through lung function in children Ann Chen Wu, MD, MPH, Martin Gregory, BA, Steven Kymes, PhD, Dennis Lambert, PhD, Joshua Edler, MS, Dustin Stwalley, MA, Anne L. Fuhlbrigge, MD, MS Journal of Allergy and Clinical Immunology Volume 130, Issue 5, Pages 1065-1070 (November 2012) DOI: 10.1016/j.jaci.2012.08.009 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Schematic of the simulation model. Each simulated child is assigned values for age and key clinical variables, which, in turn, determine the monthly probabilities of events. Journal of Allergy and Clinical Immunology 2012 130, 1065-1070DOI: (10.1016/j.jaci.2012.08.009) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Cumulative mean number of acute events per subject predicted by the simulation model compared with CAMP outcomes: placebo group. A, Cumulative mean number of ED visits. B, Cumulative mean number of hospitalizations. C, Cumulative mean number of oral corticosteroid therapies. Journal of Allergy and Clinical Immunology 2012 130, 1065-1070DOI: (10.1016/j.jaci.2012.08.009) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Cumulative mean number of acute events per subject predicted by the simulation model compared with CAMP outcomes: ICS treatment group. A, Cumulative mean number of ED Visits. B, Cumulative mean number of hospitalizations. C, Cumulative mean number of oral corticosteroid therapies. Journal of Allergy and Clinical Immunology 2012 130, 1065-1070DOI: (10.1016/j.jaci.2012.08.009) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions