Fig. 3 miRNAs that regulate whole-limb regeneration in animals are enriched in the cartilage of ankle joints, OA-affected cartilage, and cartilage superficial.

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Fig. 5 Correlation of RNA expression and protein abundance.

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Fig. 3 miRNAs that regulate whole-limb regeneration in animals are enriched in the cartilage of ankle joints, OA-affected cartilage, and cartilage superficial layer. miRNAs that regulate whole-limb regeneration in animals are enriched in the cartilage of ankle joints, OA-affected cartilage, and cartilage superficial layer. (A to C) miRNA distribution in human postnatal articular cartilage stratified by (A) joint site, (B) disease state, and (C) cartilage depth (n = 48 in total). Blastema miRNAs (miR-21, miR-31, and miR-181c) are presented as fold change from the mean expression of internal control (ctrl) miRNAs (miR-423, miR-191, and miR-U6), all quantified using miScript SYBR Green PCR Kit. P values were derived from multivariable mixed models. (D) Association of miR-21 with total protein and deamidated protein abundance. Higher miR-21 expression was consistently associated with lower deamidated protein ratio but had a less consistent association with total protein abundance. (E) The association of miR-21 with deamidated protein ratio was observed consistently in OA cartilage but less consistently in healthy cartilage. P values were derived from Pearson correlations. r = correlation. All P and r values are reported, but regression (green) lines are only shown for correlations with P < 0.05. Sup, superficial cartilage; Mid, middle depth cartilage. Ming-Feng Hsueh et al. Sci Adv 2019;5:eaax3203 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).