Fig. 3 Minimal treatment of ETL decreases metastatic burden and prolongs survival in the 4T1 breast carcinoma model after tumor resection. Minimal treatment.

Slides:

Advertisements

Similar presentations

Fig. 4 3D reconfiguration of liquid metals for electronics.

Advertisements

Fig. 5 MicroLED array with 3D liquid metal interconnects.

Fig. 3 The electrical contact of direct-printed and reconfigured liquid metals. The electrical contact of direct-printed and reconfigured liquid metals.

Fig. 2 Boronic acid–rich dendrimer in cytosolic delivery.

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Fig. 4 INS spectra of different human bones from the Roman period [humerus, ulna, femur, and fibula from the same skeleton, Guidonia-Montecelio, Italy.

Vibrational spectra of medieval human bones (Leopoli-Cencelle, Italy)

Fig. 1 Pump-probe signatures of vermilion (red HgS), black HgS, and metallic Hg. Pump-probe signatures of vermilion (red HgS), black HgS, and metallic.

Fig. 1 Map of water stress and shale plays.

Fig. 1 Examples of experimental stimuli and behavioral performance.

Fig. 1 Wireless, battery-free neural cuff for programmable pharmacology and optogenetics. Wireless, battery-free neural cuff for programmable pharmacology.

Fig. 3 Electron PSD in various regions.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Fig. 1 Mean and median RCR (Relative Citation Ratio) of Roadmap Epigenomics Program research articles for each year. Mean and median RCR (Relative Citation.

Fig. 2 CD19 CAR T cells expressing tPSMA maintain function in vitro and in vivo. CD19 CAR T cells expressing tPSMA maintain function in vitro and in vivo.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Fig. 5 In vivo evaluation of F-insulin for treatment of type 1 diabetic minipig. In vivo evaluation of F-insulin for treatment of type 1 diabetic minipig.

FTIR-ATR spectra of Neolithic faunal bones (Mora Cavorso cave, Italy)

Fig. 1 Neu1−/− fibroblasts have characteristics of myofibroblasts.

Fig. 3 FcRL1 is passively recruited into B cell immunological synapses upon BCR engagement in primary spleen B cells. FcRL1 is passively recruited into.

Fig. 5 Mutation of Y281ENV motif in FcRL1 impairs BCR engagement–induced B cell activation in the absence of FcRL1 ligation. Mutation of Y281ENV motif.

Fig. 1 Local COX-2 overexpression selectively increased the abundance and prolonged the presence of CD90+ mSSCs in the fractured bones. Local COX-2 overexpression.

Fig. 2 2D QWs of different propagation lengths.

Fig. 7 LPS enhances cochlear TRPV1 expression and GTTR uptake in vivo.

Fig. 4 EUV TG signal from Si.

Fig. 6 WPS imaging of different chemical components in living cells.

Fig. 5 Simultaneous absence of caspase-3 and -7 is required for significant decrease of caspase-8 and -9 activation in intrinsic apoptosis. Simultaneous.

Fig. 3 IRF8 is required for macrophage migration toward the epicenter in the injured spinal cord during the recovery phase. IRF8 is required for macrophage.

Fig. 1 IDH3α expression is elevated in human-derived gliomas.

Fig. 4 PSMA PET/CT enables visualization of CD19-tPSMA(N9del) CAR T cell infiltration into local and metastatic tumors. PSMA PET/CT enables visualization.

Fig. 1 Histograms of the number of first messages received by men and women in each of our four cities. Histograms of the number of first messages received.

Fig. 2 In vivo tumorigenicity of 4T1, CTC1, and DTC1 cells and EMT traits of DTC1-derived CTC lines. In vivo tumorigenicity of 4T1, CTC1, and DTC1 cells.

Fig. 4 Praying Prophet by Lorenzo Monaco: Mapping lake pigments and associated substrate. Praying Prophet by Lorenzo Monaco: Mapping lake pigments and.

Fig. 2 Magnetic properties of FGT/Pt bilayer.

Contrast agent uptake for the four different groups of MMA mice

Fig. 4 In vivo FF results for MMA mice.

Fig. 3 Production of protein and Fe(II) at the end of growth correlated with increasing concentrations of ferrihydrite in the media that contained 0.2.

Fig. 4 Dox-CBD-SA treatment shows reduced toxicity.

Fig. 4 Adenosine A2BR signaling promote osteogenic and inhibit osteoclast differentiation in vitro. Adenosine A2BR signaling promote osteogenic and inhibit.

Fig. 5 Comparison of the liquid products generated from photocatalytic CO2 reduction reactions (CO2RR) and CO reduction reactions (CORR) on two catalysts.

Fig. 6 Schematic representation of EMT during the metastatic cascade.

Fig. 1 Experimental strategy and elemental and morphological analysis of 3D/2D perovskite bilayer. Experimental strategy and elemental and morphological.

Fig. 1 Location of the Jirzankal Cemetery.

Fig. 4 CO2 emission changes triggered by the JJJ clean air policy.

Fig. 6 MSC encapsulation in vitro within PdBT cross-linked gels.

Fig. 1 Structural and electrical properties of Bi2Se3/BaFe12O19.

Fig. 2 RVFV causes pathology within the liver, uterus, and placenta of pregnant dams. RVFV causes pathology within the liver, uterus, and placenta of pregnant.

Fig. 6 Stabilization of hippocampal signaling over sleep.

Fig. 3 Comparisons of NDVI trends over the globally vegetated areas from 1982 to Comparisons of NDVI trends over the globally vegetated areas from.

AV3 potentiates the effect of gemcitabine in the PDX model in mice

Fig. 3 Heterologous TRPV1-mediated uptake of gentamicin is attenuated by extracellular [Ca2+]. Heterologous TRPV1-mediated uptake of gentamicin is attenuated.

Fig. 6 IVIS Lumina scan of mice and of their organs after intravenous administration of fluorescent LENK-SQ-Am NPs or control fluorescent dye solution.

Fig. 1 RNA methyltransferase METTL14 and demethylase ALKBH5 promote growth and invasion of breast cancer cells. RNA methyltransferase METTL14 and demethylase.

Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.

Fig. 4 Single-particle contact angle measurements.

Fig. 4 In vivo siRIPK4 delivered by HNTs inhibits tumor promotion of T24 bladder cancer cells in an in situ model of bladder cancer (n = 12 rats in each.

Fig. 5 Minimal administration of ETL is tolerable and safe in mice.

Fig. 2 Supraballs and films from binary SPs.

Fig. 3 Performance of the generative model G, with and without stack-augmented memory. Performance of the generative model G, with and without stack-augmented.

Fig. 5 The complex of antibody and dye can afford to target imaging in the NIR-II window. The complex of antibody and dye can afford to target imaging.

Fig. 4 Behavior of resistance peak near density nm = 5.

Fig. 1 Design principle and SEM characterization of super-origami DNA nanostructures with n-tuples. Design principle and SEM characterization of super-origami.

Fig. 1 Overview of amber clast with synchrotron x-ray μCT image of articulated snake skeleton (DIP-S-0907). Overview of amber clast with synchrotron x-ray.

Fig. 1 ETL kills 4T1 breast carcinoma cells more efficiently than ST under static conditions. ETL kills 4T1 breast carcinoma cells more efficiently than.

Fig. 1 Architected materials fabrication by projection microstereolithography–based additive manufacturing using poly(ethylene glycol) diacrylate resin.

Fig. 3 Supercurrents in various conductance plateau regions.

Fig. 4 Effects of individual picosecond and microsecond pulses.

Fig. 6 tlr2 is necessary for SASP activation in vivo.

Fig. 5 Controlled tumor growth inhibition study of the self-assembled nanostructures. Controlled tumor growth inhibition study of the self-assembled nanostructures.

Fig. 5 CD19-tPSMA(N9del) CAR T cell numbers in mouse and human.

Presentation transcript:

Fig. 3 Minimal treatment of ETL decreases metastatic burden and prolongs survival in the 4T1 breast carcinoma model after tumor resection. Minimal treatment of ETL decreases metastatic burden and prolongs survival in the 4T1 breast carcinoma model after tumor resection. (A) Timeline of in vivo experiment. i.v., intravenous; i.p., intraperitoneal. (B) Photomicrographs (H&E stain) of the isolated primary tumors taken (scale bars, 1 mm) to show the tumor size and central necrosis in ST-, NL-, and ETL-treated mice followed by (C) graphical representation of the ratio of necrotic area to tumor area after digitization and image analysis. (D) Antimetastatic effect of ETL in vivo, as shown by IVIS imaging of bioluminescence in 4T1 metastatic breast carcinoma mice that received mammary fat pad transplant of 4T1-luc cells (4T1 cells stably expressing luciferase) and were treated with three injections of ST, NL, or ETL (50 μg per injection; before, during, and after tumor resection within a period of 6 days; n = 10). IVIS imaging was performed at day 13 and day 8 after the first and last injections, respectively. Graphical representation of quantitation of IVIS imaging of (E) overall luciferase signal. (F) Mouse body weight during the course of the in vivo study at indicated time points (Fig. 4A; mean ± SEM; n = 10). (G) Survival of 4T1 metastatic breast carcinoma mice that received mammary fat pad transplant of 4T1-luc cells and were treated with three injections of ST, NL, or ETL (50 μg per injection), designating the transplantation date as day 0 (n = 10). (H) Photomicrographs of the lung (scale bar, 500 μm) and liver (scale bar, 100 μm) to show metastatic foci in NL and ETL treatment groups, respectively, with a focus of vascular space invasion in lung compared to the small metastatic foci in the liver (T) with extramedullary hematopoiesis (asterisks). (I) Photomicrographs of distal femur and proximal tibia (scale bars, 250 μm) to show bone metastasis. *P < 0.05 and **P < 0.005. Nidhi Jyotsana et al. Sci Adv 2019;5:eaaw4197 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).