Quantification of biomarker candidates in prediagnostic plasmas from mouse models of colorectal cancer. Quantification of biomarker candidates in prediagnostic.

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Quantification of biomarker candidates in prediagnostic plasmas from mouse models of colorectal cancer. Quantification of biomarker candidates in prediagnostic plasmas from mouse models of colorectal cancer. A, log2-transformed case/control ratios of AK1 and SOD1 levels in plasma from Apc- and Msh2-deficient mice with low-grade adenoma and high-grade adenoma compared with controls. B, log2-transformed case/control ratios of CLIC1 levels in plasma from a mouse with oncogenic KrasG12D-induced colorectal cancer compared with controls. Plasma samples were collected at 0 weeks, 2 weeks, and 4 weeks (the mice were sacrificed at 5 weeks) after induction of KrasG12D from mice in which colon adenocarcinoma developed, and those samples were compared with a pool of plasma samples from 5 sex-matched mice without tumors. Ayumu Taguchi et al. Cancer Prev Res 2015;8:1112-1119 ©2015 by American Association for Cancer Research