SCLC initiated from pulmonary neuroendocrine cells metastasizes without upregulating NFIB. A and B, Mouse models of SCLC. Rb1flox/flox;Trp53flox/flox;p130flox/flox;R26mTmG.

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Volume 19, Issue 6, Pages (June 2011)

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SCLC initiated from pulmonary neuroendocrine cells metastasizes without upregulating NFIB. A and B, Mouse models of SCLC. Rb1flox/flox;Trp53flox/flox;p130flox/flox;R26mTmG (TKO;mTmG) mice were transduced with either Adeno-CMV-Cre (“CMV TKO”) or Adeno-CGRP-C... SCLC initiated from pulmonary neuroendocrine cells metastasizes without upregulating NFIB. A and B, Mouse models of SCLC. Rb1flox/flox;Trp53flox/flox;p130flox/flox;R26mTmG (TKO;mTmG) mice were transduced with either Adeno-CMV-Cre (“CMV TKO”) or Adeno-CGRP-Cre (“CGRP TKO”) to initiate SCLC. C and D, Representative hematoxylin and eosin (H&E) images of SCLC tumors from CMV TKO and CGRP TKO mice. Immunostaining for NFIB on primary tumors and metastases is shown. Scale bars, 100 μm. E, Quantification of NFIB expression in primary tumors and liver metastases (met) from CMV TKO and CGRP TKO mice. F, Representative immunostaining for NFIB on human SCLC brain metastases. Expression score for NFIB is indicated. Scale bars, 100 μm. G, Quantification of NFIB expression in human SCLC metastases (including lymph node and brain metastases, N = 43). CGRP, calcitonin gene-related peptide. Dian Yang et al. Cancer Discov 2018;8:1316-1331 ©2018 by American Association for Cancer Research