Designer Genes and Engineered Circuits

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Presentation transcript:

Designer Genes and Engineered Circuits Cell Volume 157, Issue 5, (May 2014) DOI: 10.1016/j.cell.2014.05.014 Copyright © 2014 Terms and Conditions

The designer synthetic chromosome synIII, based on chromosome III of the budding yeast Saccharomyces cerevisiae. Image courtesy of J. Boeke. Cell 2014 157, DOI: (10.1016/j.cell.2014.05.014) Copyright © 2014 Terms and Conditions

The unnatural base pair formed between the predominantly hydrophobic nucleotides d5SICS-dNaM is efficiently replicated within E. coli by the native replication machinery. Courtesy of J. Chin. Cell 2014 157, DOI: (10.1016/j.cell.2014.05.014) Copyright © 2014 Terms and Conditions

The XTMS interactive platform ranks promiscuous enzymatic steps, toxicities, and yields to facilitate exploration of prospective biosynthetic pathways. Courtesy of J.-L. Faulon. Cell 2014 157, DOI: (10.1016/j.cell.2014.05.014) Copyright © 2014 Terms and Conditions