Cyclooxygenase (COX) independent chemopreventive mechanisms of non-steroidal anti-inflammatory drugs (NSAIDs). *Genes with a T cell factor 4 responsive.

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Douglas K Rex, MD, FACG Journal of Pain and Symptom Management

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Presentation transcript:

Cyclooxygenase (COX) independent chemopreventive mechanisms of non-steroidal anti-inflammatory drugs (NSAIDs). *Genes with a T cell factor 4 responsive element in their promoter, but no reports of downregulation in response to NSAIDs. **Contradictory reports. Cyclooxygenase (COX) independent chemopreventive mechanisms of non-steroidal anti-inflammatory drugs (NSAIDs). *Genes with a T cell factor 4 responsive element in their promoter, but no reports of downregulation in response to NSAIDs. **Contradictory reports. PPAR, peroxisome proliferator activated receptor; TGF-β, transforming growth factor β; NFκB, nuclear factor κB; VEGF, vascular endothelial growth factor; TRAIL, tumour necrosis factor related apoptosis inducing ligand. L A A Brosens et al. Gut 2005;54:1034-1043 Copyright © BMJ Publishing Group Ltd & British Society of Gastroenterology. All rights reserved.