Serial MR images in a patient receiving hydroxyurea.

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Presentation transcript:

Serial MR images in a patient receiving hydroxyurea. Serial MR images in a patient receiving hydroxyurea. The first examination was performed at another institution.A, Examination 1. T1-weighted image shows mild atrophy in the left medial frontal lobe.B, Examination 1. Fluid-attenuated inversions recovery image demonstrates a recent infarction in the right middle cerebral artery territory, as well as a remote left anterior cerebral artery infarct, bilateral deep white matter leukoencephalopathy, and a few scattered deep white matter lacunae.C, Examination 2. Image obtained at our institution almost 1 year after the beginning of therapy shows further progression of mild diffuse cerebral atrophy.D, Examination 5. Approximately 4 years after the beginning of hydroxyurea therapy moderate diffuse cerebral atrophy is present, with prominent sulci and further ex vacuo dilatation of the ventricular system. Kathleen J. Helton et al. AJNR Am J Neuroradiol 2002;23:1692-1696 ©2002 by American Society of Neuroradiology