γδ T cells producing IL-17 are required for short-term memory.

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γδ T cells producing IL-17 are required for short-term memory. γδ T cells producing IL-17 are required for short-term memory. (A) Representative track line from indicated animals exploring the short-term Y-maze. (B to D) Cognitive performance in the short-term Y-maze evaluated by discrimination ratio between the novel arm (N) versus the other arm (O) of IL-17−/− and TCRδ−/− compared with respective littermate controls (n = 21 to 32) (B), WT ➔ WT BMC mice (n = 23 to 27) (C), and WT after intracerebroventricular injection of isotype control (IgG) or anti–IL-17 (aIL-17) (n = 10 to 12) (D). (E) Percentages of swimming time in the test quadrant of IL-17−/− and TCRδ−/− and respective littermate controls during the probe test of the long-term MWM (n = 10 to 14). (F) Cognitive performance in the long-term Y-maze evaluated by discrimination ratio between the novel arm (N) versus the other arm (O) of IL-17−/− and TCRδ−/− compared with respective littermate controls (n = 10 to 16). (G) Representative track line from indicated animals exploring the short-term MWM during the probe test, after a training phase with a platform in the lower left quadrant of the pool. (H) Corresponding percentages of time spent in the test quadrant of IL-17−/− and TCRδ−/− and respective littermate controls (n = 8 to 16). Results are representative of two to three independent experiments in male mice. Error bars, mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001. Paired Student’s t test and one-way ANOVA followed by Bonferroni’s multiple comparison test were used to analyze discrimination ratio (%) and time in quadrant (%), respectively. Miguel Ribeiro et al. Sci. Immunol. 2019;4:eaay5199 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works