Use of a low-resistance compliant thoracic artificial lung in the pulmonary artery to pulmonary artery configuration Christopher N. Scipione, MD, Rebecca.

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Presentation transcript:

Use of a low-resistance compliant thoracic artificial lung in the pulmonary artery to pulmonary artery configuration Christopher N. Scipione, MD, Rebecca E. Schewe, MS, Kelly L. Koch, BS, Andrew W. Shaffer, MD, Amit Iyengar, Keith E. Cook, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 145, Issue 6, Pages 1660-1666 (June 2013) DOI: 10.1016/j.jtcvs.2013.01.020 Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 The cTAL demonstrating the blood and gas flow paths. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 1660-1666DOI: (10.1016/j.jtcvs.2013.01.020) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Experimental pulmonary system setup with all resistive elements. The shunt includes the anastomoses (Ain and Aout), the cTAL, and the flow occluder. cTAL, Compliant thoracic artificial lung; pPAP, proximal pulmonary artery pressure; Ain, inlet anastomosis; Aout, outlet anastomosis; dPAP, distal pulmonary artery pressure; LAP, left atrial pressure. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 1660-1666DOI: (10.1016/j.jtcvs.2013.01.020) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 CO (A) and MAP (B) versus the percentage of CO shunted to the compliant artificial lung for dobutamine doses of 0 μg/kg/min and 5 μg/kg/min. BL, Baseline; cTAL, compliant thoracic artificial lung; MAP, mean arterial pressure. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 1660-1666DOI: (10.1016/j.jtcvs.2013.01.020) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Total pulmonary system resistance, PVR, and shunt resistance at varying percentages of CO diverted to the compliant artificial lung for dobutamine doses of (A) 0 μg/kg/min and (B) 5 μg/kg/min. RT, Total pulmonary system resistance; Rs, shunt resistance; Dob, dobutamine; PVR, pulmonary vascular resistance; BL, baseline; cTAL, compliant thoracic artificial lung. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 1660-1666DOI: (10.1016/j.jtcvs.2013.01.020) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Mean pPAP versus the percentage of CO shunted to the compliant artificial lung for dobutamine doses of 0 μg/kg/min and 5 μg/kg/min. BL, Baseline; cTAL, compliant thoracic artificial lung. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 1660-1666DOI: (10.1016/j.jtcvs.2013.01.020) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions