Fig. 1 Generation and characterization of MeV-based vaccine candidates for Lassa virus. Generation and characterization of MeV-based vaccine candidates.

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MP cells, but not pathogen-elicited effector CD4+ T lymphocytes, rapidly produce IFN-γ during T. gondii infection independently of pathogen antigens. MP.

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IFN-γ activates the fibrinolytic system.

MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific T-bet+ population. MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific.

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Tukey boxplots overlaid on data points from objective and subjective measures, displaying results from study 1. Tukey boxplots overlaid on data points.

DC subset cooperation for activation of antiviral T cells.

Donor and recipient BAL T cells are phenotypically and functionally memory T cells. Donor and recipient BAL T cells are phenotypically and functionally.

Fig. 7 Correlation of NHP and human ISGs.

Donor TRM persistence is associated with reduced clinical complications. Donor TRM persistence is associated with reduced clinical complications. Patient.

T-bethi MP cells produce IFN-γ in response to IL-12.

Differentiation of AZD4785 from MAPK pathway inhibitors in vitro

Fig. 6 In utero injection of inflammatory cytokines or adoptive transfer of activated T cells leads to pregnancy loss. In utero injection of inflammatory.

Fig. 5 Correlation of RNA expression and protein abundance.

IFN-γ antagonizes TGF-β in vivo.

Fig. 4. Peanut-specific TH2A cells are specifically targeted during immunotherapy. Peanut-specific TH2A cells are specifically targeted during immunotherapy.

Fig. 2 AdOPG transduction changes RANKL/OPG homeostasis in primary hMSCs differentiated on Col-GAG and MC-GAG. AdOPG transduction changes RANKL/OPG homeostasis.

Fig. 5 Hypoxic tumors from obese mice associate with increased production of IL-6 by adipocytes and myeloid cells. Hypoxic tumors from obese mice associate.

Fig. 2 AcPGP induces IL-8 and G-CSF release from human bronchial epithelial cells. AcPGP induces IL-8 and G-CSF release from human bronchial epithelial.

Cell viability tests. Cell viability tests. SEM images of (A) MC3T3-E1 cells and (B) MSCs on days 1, 3, and 5 of culture. (C) Survival rates of MC3T3-E1.

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Fig. 4. PVSRIPO infection of DCs is sublethal, is marginally productive, and induces sustained proinflammatory cytokine production. PVSRIPO infection of.

MP cells, but not pathogen-elicited effector CD4+ T lymphocytes, rapidly produce IFN-γ during T. gondii infection independently of pathogen antigens. MP.

Fig. 4 High P-eIF2α expression in human prostate tumors with loss of PTEN function is associated with increased risk of metastasis or death after surgery.

Innate immune and fibrinolytic systems cooperate also during bacterial infections. Innate immune and fibrinolytic systems cooperate also during bacterial.

CD25 expression identifies two transcriptionally distinct subsets of very early effector cells. CD25 expression identifies two transcriptionally distinct.

Fig. 1. Potent and selective down-regulation of KRAS mRNA and protein by AZD4785 in vitro and in vivo. Potent and selective down-regulation of KRAS mRNA.

Fig. 3. Increased expression of exhaustion markers and apoptosis markers on CAR8 cells in the presence of TCR antigen. Increased expression of exhaustion.

Fig. 3 BMS blocks functional responses in primary immune cells driven by IL-23 and IL-12. BMS blocks functional responses in primary immune.

Fig. 5 EGLN2-mediated HIF1A down-regulation promotes ferroptosis.

Fig. 1. DEL-1 is expressed by human and mouse osteoclasts.

Fig. 7 BMS reduces the elevated expression of type I IFN–regulated genes both ex vivo in blood from patients with lupus and in a phase 1 study of.

BMS blocks functional responses in primary immune cells driven by IFNα

Fig. 1 Bioinspired design of AAD for promoting wound contraction.

Fig. 6 SNP rs is a functional SNP in 22Rv1 cells.

Fig. 4 HRI regulates BCL11A levels.

Fig. 1 Distribution of total and fake news shares.

S-Affs colocalize with SUMO in mammalian cells.

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Fig. 2 ObR is cleaved and has reduced signaling capabilities after incubation with Mmp-2. ObR is cleaved and has reduced signaling capabilities after incubation.

Fig. 3 Production of protein and Fe(II) at the end of growth correlated with increasing concentrations of ferrihydrite in the media that contained 0.2.

GSDMD localizes to the plasma membrane and is processed during NET formation. GSDMD localizes to the plasma membrane and is processed during NET formation.

Fig. 5. Vascularization of human liver seed grafts.

Fig. 2 Neonatal ZIKV infection induces seizures in young mice and increases susceptibility to chemically induced seizures in adult mice. Neonatal ZIKV.

Fig. 3 DUB proteins act at different levels of type I IFN pathways.

Fig. 6 Antitumor effect on tumor growth and pulmonary metastasis of CSSD-9 in vivo. Antitumor effect on tumor growth and pulmonary metastasis of CSSD-9.

Fig. 1 Scheme for a multivariate linear combination in living cells.

Bio-AMS enhances the activity of rifampicin and ethambutol in vitro

Fig. 5 C9orf72 knockdown disrupts autophagy induction.

Fig. 2 Increasing KLF17, CDH1, and LASS2 expression reduced malignant progression and promoted apoptosis of tumor cells. Increasing KLF17, CDH1, and LASS2.

Fig. 5. High burdens of AA signature mutations and predicted immunogenicity in Taiwan HCCs. High burdens of AA signature mutations and predicted immunogenicity.

Fig. 3 Effects of ASO and eGLP1-ASO conjugates on gene expression and protein levels in vitro in cell lines and primary mouse islet cells. Effects of ASO.

Fig. 7 BEL immune response.

Fig. 3 Superiority of BAFF-R versus CD19-CAR T cells in a Burkitt lymphoma model is not due to greater tumor antigen density. Superiority of BAFF-R versus.

Fig. 5 LASV replication in cynomolgus monkeys.

Fig. 1 A large number of DUBs are regulated by virus-induced type I IFN signaling at the transcriptional level. A large number of DUBs are regulated by.

Fig. 4 Behavior of resistance peak near density nm = 5.

Fig. 6 Methionine oxidation catalyzed by viperin increases the stability and function of RNA helicase RIG-I. Methionine oxidation catalyzed by viperin.

Fig. 8 Immune correlates of protection.

In vivo function of MeTro sealants using rat incision model of lungs

Fig. 2 hTERT induces expression of heat shock protein genes through HSF1 and interacts with Hsp70-1. hTERT induces expression of heat shock protein genes.

Fig. 5 Treatment with molecules 13, 14, and 15 decreases HIV-1 R5 infection in human macrophages. Treatment with molecules 13, 14, and 15 decreases HIV-1.

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Fig. 4 Rotavirus induces the type I IFN pathway and release of ATP by tumor cells. Rotavirus induces the type I IFN pathway and release of ATP by tumor.

Presentation transcript:

Fig. 1 Generation and characterization of MeV-based vaccine candidates for Lassa virus. Generation and characterization of MeV-based vaccine candidates for Lassa virus. (A) Scheme of the MeV-based vaccines generated using the Schwarz strain. ATU, additional transcription unit. (B) Growth kinetics of vaccines in Vero NK cells. The results are presented as the means ± SEM of three independent experiments. (C) LASV NP, GPC, Z protein, and MeV F antigen expression in supernatants and cell extracts (cells) of infected Vero NK cells analyzed by Western blot. Actin was used to normalize the amount of loaded proteins. (D) Induction of type I IFN mRNA expression in primary human monocyte-derived dendritic cells (left graph) and macrophages (right graph) 1 day after infection by the MeV-based constructs. (E) Cell surface expression of coactivation molecules in primary human monocyte-derived dendritic cells (left graph) and macrophages (right graph) at day 2 after infection. Results (D and E) are presented as the means ± SEM of three or more independent experiments using different donors. (F) Infection of CHO-K1 or CHO-hCD46 cells by MOPEVACLAS or MeV-NP using an MOI of 1. LASV GPC (green) was detected by immunofluorescence 72 hours after infection. Nuclei are stained with DAPI (blue). Mathieu Mateo et al., Sci Transl Med 2019;11:eaaw3163 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works