West African Ebola Virus Strains: Unstable and Ready to Invade?

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Presentation transcript:

West African Ebola Virus Strains: Unstable and Ready to Invade? Christopher F. Basler Cell Host & Microbe Volume 21, Issue 3, Pages 316-318 (March 2017) DOI: 10.1016/j.chom.2017.02.017 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Impact of A82V on Ebola Virus Glycoprotein Function Changes at residue 82 of the Ebola virus (EBOV) glycoprotein (GP) enhance entry into human cells by altering dependence on host factors. Several studies now implicate an A82V change in the EBOV GP as enhancing viral entry into human cells. Wang et al. (2017) now demonstrate that A82V alters the dependence of GP on host factors, including cathepsins and NPC-1, to facilitate entry into human cells. How this change affects virulence in vivo remains to be defined. Cell Host & Microbe 2017 21, 316-318DOI: (10.1016/j.chom.2017.02.017) Copyright © 2017 Elsevier Inc. Terms and Conditions