WEE1 inhibition followed by TRAIL treatment results in apoptotic cell death in MB231 cells. WEE1 inhibition followed by TRAIL treatment results in apoptotic.

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WEE1 inhibition followed by TRAIL treatment results in apoptotic cell death in MB231 cells. WEE1 inhibition followed by TRAIL treatment results in apoptotic cell death in MB231 cells. A, the percentage of cells with sub-G1 DNA content was measured by propidium iodide staining after 21 hours of WEE1 (10 μmol/L) inhibition or 17 hours of treatment with TRAIL (100 ng/mL) or pretreatment with WEE1 inhibitor (10 μmol/L) for 4 hours followed by TRAIL treatment (100 ng/mL) for 17 hours. The graph represents the mean values ± SEM of 3 independent experiments. B, the percentage of Annexin V-positive cells seen following the treatment with WEE1 inhibitor or TRAIL or the combination of both as described above. The graph represents the mean values ± SEM of 3 independent experiments. Sireesha V. Garimella et al. Mol Cancer Res 2012;10:75-85 ©2012 by American Association for Cancer Research