A: Glucose levels during basal-bolus and SSI treatment. A: Glucose levels during basal-bolus and SSI treatment. Changes in blood glucose concentration after the 1st day of treatment with basal-bolus with glargine once daily plus glulisine before meals (○) and with SSI 4-times daily (●). *P < 0.001, ŧP = 0.02, †P = 0.01. B: Glucose levels before meals and bedtime. Premeal and bedtime glucose levels were higher throughout the day in the SSI group (●) compared with basal-bolus regimen (○). Guillermo E. Umpierrez et al. Dia Care 2011;34:256-261 ©2011 by American Diabetes Association