Risk factors for primary graft dysfunction after lung transplantation

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Presentation transcript:

Risk factors for primary graft dysfunction after lung transplantation Bryan A. Whitson, MD, Dilip S. Nath, MD, Adam C. Johnson, MD, Adam R. Walker, BS, Matthew E. Prekker, MD, David M. Radosevich, PhD, Cynthia S. Herrington, MD, Peter S. Dahlberg, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 131, Issue 1, Pages 73-80 (January 2006) DOI: 10.1016/j.jtcvs.2005.08.039 Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Prevalence and 90-day survival of patients with grade 3 primary graft dysfunction (PGD). A, Point prevalence of International Society for Heart and Lung Transplantation grade 3 PGD at each individual time during the first 48 hours is represented by the open bars. The cumulative percentage of grade 3 prevalence is shown in the filled bars. B, Percentage of patients dying within 90 days after surgical intervention stratified by whether (filled bars) or not (open bars) the patient had grade 3 PGD at each time point after the operation and as a worst grade 48-hour end point (last set of bars). The differences in 90-day death rates among groups were significantly different (P < .05, χ2 test) at all time points. The Journal of Thoracic and Cardiovascular Surgery 2006 131, 73-80DOI: (10.1016/j.jtcvs.2005.08.039) Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Long-term survival stratified by modified primary graft dysfunction grade. Kaplan-Meier actuarial survival curves are stratified by modified International Society for Heart and Lung Transplantation (ISHLT) grade. Patients with grade 3 primary graft dysfunction had a significantly reduced survival compared with those with grade 1 and grade 2 primary graft dysfunction (median survival grade 3, 4.6 years; grade 2, 6.6 years; grade 1, 7.5 years; P = .006, log-rank test). Grade 1 is represented in dark dray, grade 2 is represented in light gray with hatching, and grade 3 is represented in black. The Journal of Thoracic and Cardiovascular Surgery 2006 131, 73-80DOI: (10.1016/j.jtcvs.2005.08.039) Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Adjusted odds of severe primary graft dysfunction (PGD). A, Multivariate adjusted odds of PGD according to donor age. Individual points represent the mean odds of groups of 40 patients. The first data grouping was used as the reference. B,Multivariate adjusted odds of PGD according to pulmonary artery (PA) pressure. Individual points represent the mean odds of groups of 40 patients. The first data grouping was used as the reference. The Journal of Thoracic and Cardiovascular Surgery 2006 131, 73-80DOI: (10.1016/j.jtcvs.2005.08.039) Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions