Nathan R. Treff, Ph. D. , Jessyca Campos, M. S. , Xin Tao, M. S

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Presentation transcript:

Blastocyst preimplantation genetic diagnosis (PGD) of a mitochondrial DNA disorder Nathan R. Treff, Ph.D., Jessyca Campos, M.S., Xin Tao, M.S., Brynn Levy, Ph.D., Kathleen M. Ferry, B.S., Richard T. Scott, M.D. Fertility and Sterility Volume 98, Issue 5, Pages 1236-1240 (November 2012) DOI: 10.1016/j.fertnstert.2012.07.1119 Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Single- and five-cell lymphocyte sample mutation loads. (A) Single- and five-cell samples from the daughter and patient with respect to the expected loads of 84% and 35%, respectively. (B) Variation in the single-cell, five-cell, and single-cell-equivalent samples. Fertility and Sterility 2012 98, 1236-1240DOI: (10.1016/j.fertnstert.2012.07.1119) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Mean (±SD where applicable) mutation loads in trophectoderm and inner cell mass from 6 blastocysts. Fertility and Sterility 2012 98, 1236-1240DOI: (10.1016/j.fertnstert.2012.07.1119) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions