FIGURE 1 WT CD2 TG CD25 CONTROL IL-2 CD3/CD28 CD3/CD28+IL

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FIGURE 1 WT CD2 TG CD25 CONTROL IL-2 CD3/CD28 CD3/CD28+IL-2 74.3 9.9 74.3 9.9 89.4 6.8 45.4 52 50.7 47.9 WT TG CD2 84.1 9.1 85.4 10.6 42.2 56.1 41.5 56 CD25 FIGURE 1

FIGURE 2 WT TG Thymidine Uptake (cpm) IL-2 Control CD3/CD28 2000 4000 6000 8000 10000 12000 14000 16000 18000 20000 Control CD3/CD28 IL-2 IL-2 + CD3/CD28 WT TG Thymidine Uptake (cpm) FIGURE 2

FIGURE 3 WT TG ** * Unstimulated Anti-CD3/CD28 IL-10 (ng/mL) 0,5 1 1,5 2 2,5 200 400 600 800 1000 1200 20 40 60 80 100 120 10 30 50 70 0,1 0,2 0,3 0,4 0,6 ** * IL-10 (ng/mL) IL-4 (pg/mL) IL-13 (pg/mL) IFN- (ng/mL) IL-2 (ng/mL) Unstimulated Anti-CD3/CD28 FIGURE 3 WT TG

* FIGURE 4 IL-2 + anti-CD3/28 IL-2 anti-CD3/28 Unstimulated CD4+ CD8+ 10 20 30 40 50 60 anti-CD3/28 Unstimulated CD4+ CD8+ 70 FIGURE 4 PERCENTAGE OF CELL NUMBER WT TG

FIGURE 5 WT TG WT TG T CD4 CD8 10 20 30 40 50 60 70 % CELL NUMBER * 80 10 20 30 40 50 60 70 T CD4 CD8 % CELL NUMBER * 80 100 120 140 CELL NUMBER WT TG WT TG FIGURE 5